雌激素联合抗抑郁药物治疗我国围绝经期妇女抑郁效果评价的Meta分析

发布时间：2018-03-01 12:04

本文关键词： 雌激素类围绝经期抑郁症联合治疗 Meta分析　出处：《重庆医学》2017年24期 　论文类型：期刊论文

【摘要】：目的系统评价雌激素联合抗抑郁药物治疗我国围绝经期妇女抑郁症状的临床疗效。方法计算机检索中国生物医学文献光盘数据库(CBMdisc)、中国知网(CNKI)、万方数据知识服务平台、PubMed、Cochrane Library和Google学术等电子数据库,设置主题词检索1980年1月至2016年2月国内外发表的关于雌激素联合抗抑郁药物治疗我国围绝经期妇女抑郁的临床效果评价的相关文献。应用RevMan5.1软件对纳入文献的研究数据及结果进行Meta分析。结果共纳入15篇符合纳入标准的文献。数据合并结果显示,与单独使用雌激素治疗组相比,雌激素联合抗抑郁药物治疗组在有效率(RR=1.46,95%CI=1.29~1.66,P0.01)、HAMD评分(WMD=-4.61,95%CI=-5.63~-3.59,P0.01)和KMI评分(WMD=-5.83,95%CI=-11.12~-0.53,P0.01)3个方面差异有统计学意义。结论雌激素替代治疗联合抗抑郁药物对临床围绝经期症状及抑郁症状的治疗及缓解效果显著优于单独使用雌激素替代治疗。
[Abstract]:Objective to evaluate the clinical efficacy of estrogen combined with antidepressants in the treatment of depression in Chinese menopausal women. Electronic databases such as the PubMedine Cochrane Library and Google academic, To search the literature published from January 1980 to February 2016 on the evaluation of clinical efficacy of estrogen combined with antidepressants in the treatment of depression in menopausal women in China. The data and results of the study were analyzed by Meta. The results were included in 15 articles that met the inclusion criteria. Compared with the estrogen treatment group alone, The effective rate of estrogen combined with antidepressant therapy group was significantly different in three aspects: the effective rate of estrogen combined with antidepressant therapy was 1.29 ~ 1.66N P0.01a Hamd score and WMD-5.63 ~ -3.59% P0.01) and KMI score WMD-5.8395CI-11.12 ~ (12) -0.53N P0.01.Conclusion estrogen replacement therapy combined with antidepressant therapy has statistical significance in the treatment of peri-menopausal and depressive symptoms in patients with menopausal and depressant symptoms. [WT5HZ] [WT5BZ] there are significant differences in the efficacy of estrogen replacement therapy combined with antidepressant drugs in the treatment of peri-menopausal and depressive symptoms. The therapeutic and palliative effects were significantly better than that of estrogen replacement therapy alone.
【作者单位】：广东省江门市第三人民医院精神二科;
【分类号】：R749.4

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