八种抗精神病药物治疗女性精神分裂症患者的疗效及不良反应分析

发布时间：2018-03-02 10:08

本文关键词： 抗精神病药精神分裂症女性疗效不良反应　出处：《哈尔滨医科大学学报》2014年04期 　论文类型：期刊论文

【摘要】：目的观察八种抗精神病药对女性精神分裂症患者的疗效及不良反应。方法共纳入685例女性精神分裂症患者,分别接受奥氮平(10~30 mg/天)、喹硫平(500~750 mg/天)、利培酮(2~5.5 mg/天)、阿立哌唑(15~30 mg/天)、氟哌啶醇(10~30 mg/天)、氯氮平(150~450 mg/天)、舒必利(0.6~1.2/天)、齐拉西酮(80~160 mg/天)治疗,观察疗效和不良反应。结果八种抗精神病药对女性精神分裂症患者的疗效无显著性差异,对女性患者代谢的影响从大到小依次为氯氮平、奥氮平、喹硫平、氟哌啶醇、利培酮、齐拉西酮、舒必利、阿立哌唑;对女性患者内分泌影响最明显的是利培酮和舒必利;药源性焦虑以利培酮出现的比率最高;导致女性患者排尿困难最常见于阿立哌唑。结论应根据患者的不同年龄、对药物的疗效及不良反应出现的个体差异,做到用药个体化。
[Abstract]:Objective to observe the efficacy and side effects of eight antipsychotics on female schizophrenic patients. Methods 685 female schizophrenic patients were included in the study. They were treated with olanzapine 1030 mg / d, quinthiapine 500 ~ 750 mg / d, risperidone 25.5 mg / day, aripiprazole 1530 mg / day, haloperidol 1010 ~ 30 mg / day, clozapine 150 450 mg / d, sulpiride 0.61.2 / d, ziprasidone 80160 mg / day. Results there was no significant difference in the efficacy of the eight antipsychotics in female patients with schizophrenia. The effects on the metabolism of female patients were clozapine, olanzapine, quinthiapine, haloperidol, risperidone, respectively. Ziprasidone, sulpiride, aripiprazole, risperidone and sulpiride had the most obvious endocrine effects on female patients, the incidence of drug-induced anxiety was the highest. Aripiprazole is the most common cause of dysuria in female patients.
【作者单位】：哈尔滨医科大学附属第一医院精神科;哈尔滨医科大学附属第四医院普外科;
【基金】：黑龙江省卫生厅课题(2007-282)
【分类号】：R749.3

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