丁苯酞对血管性轻度认知功能障碍患者S100和MBP的影响

发布时间：2018-03-02 10:21

本文关键词： 血管性轻度认知功能障碍丁苯酞 S MBP　出处：《中国医院药学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:探讨丁苯酞软胶囊治疗血管性轻度认知功能障碍的临床疗效以及对血浆MBP、S100浓度的影响。方法:将60例血管性轻度认知障碍患者(按随机数字表法)随机分为2组,每组30人,治疗组给予基础药物治疗加口服丁苯酞软胶囊治疗,对照组给予基础药物,疗程为12个月,于治疗前、治疗后第6个月、12个月分别对患者进行简易精神状态检查(MMSE),测定S100和MBP浓度。结果:治疗组6个月、12个月时MMSE评分与对照组比较有明显改善,S100和MBP浓度显著下降。结论:丁苯酞软胶囊可有效提高血管性轻度认知功能障碍患者MMSE评分并降低S100和MBP浓度,具有神经保护作用。
[Abstract]:Objective: to investigate the clinical effect of butyphthalide soft capsule in the treatment of vascular mild cognitive impairment and its effect on plasma MBPnS100. Methods: sixty patients with mild vascular cognitive impairment were randomly divided into two groups. Each group of 30 people, the treatment group was treated with basic drugs plus oral butyphthalide soft capsule treatment, the control group was given basic drugs for 12 months, before treatment, After 6 months and 12 months of treatment, the patients were examined with simple mental state and the concentrations of S100 and MBP were measured. Results: the MMSE score of the treatment group at 6 months and 12 months after treatment was significantly improved compared with that of the control group. Conclusion: butyphthalide soft capsule can effectively improve the MMSE score and reduce the concentration of S 100 and MBP in patients with vascular mild cognitive impairment. It has neuroprotective effect.
【作者单位】：河北省人民医院;
【分类号】：R749.13

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