腺苷受体参与阿尔茨海默病的研究进展

发布时间：2018-03-05 06:04

本文选题：腺苷　切入点：腺苷受体　出处：《药学学报》2014年06期 　论文类型：期刊论文

【摘要】：腺苷是一种重要的神经调质,主要通过腺苷受体发挥各种生理作用。近年研究发现腺苷受体的分布、类型及表达变化等与学习记忆等认知功能关系密切,在阿尔茨海默病(Alzheimer’s disease,AD)等神经退行性疾病发病中发挥了重要作用。目前的研究结果表明,受各种损伤因素的影响,腺苷受体被高水平的腺苷持续激活而导致脑内腺苷受体的失衡,主要表现为A1受体表达减少和A2a受体表达升高,以及A1受体介导抑制作用的减弱和A2a受体介导兴奋作用的增强,进而通过各自介导的信号通路引起一系列神经病理变化,最终导致认知功能障碍。维持腺苷受体的平衡可能是防治AD的一个重要途径,对其深入研究有助于进一步了解AD的发病机制,并提供新的治疗方向和思路。
[Abstract]:Adenosine is an important neuromodulator that plays a variety of physiological roles mainly through adenosine receptors. In recent years, it has been found that the distribution, type and expression of adenosine receptors are closely related to cognitive functions such as learning and memory. It plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Current studies have shown that adenosine receptors are continuously activated by high levels of adenosine, resulting in the imbalance of adenosine receptors in the brain. The main manifestations were the decrease of A1 receptor expression and the increase of A2a receptor expression, as well as the decrease of A1 receptor mediated inhibition and the enhancement of A2a receptor-mediated excitation, which resulted in a series of neuropathological changes through the respective signaling pathways. Maintaining the balance of adenosine receptor may be an important way to prevent and treat AD. Further study on it will help to further understand the pathogenesis of AD and provide a new treatment direction and ideas.
【作者单位】：军事医学科学院毒物药物研究所;广州中医药大学临床药理研究所;
【基金】：国家自然科学基金资助项目(81100239,81302759) 国家重大新药创制科技重大专项课题资助项目(2012ZX09301003-002)
【分类号】：R96;R749.16

【相似文献】