快速认知筛查测验识别老年轻度认知功能障碍的效果

发布时间：2018-03-05 08:04

本文选题：轻度认知功能障碍　切入点：阿尔茨海默病　出处：《中国老年学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的评价老年人快速认知筛查测验识别轻度认知功能障碍(MCI)和早期痴呆(AD)的效能。方法 60岁及以上的轻度AD患者84例、MCI患者112例、正常老人(NC)196例,采用老年人快速认知筛查测验(QCST-E)、简易精神状态检查量表(MMSE)、日常生活能力(ADL)量表、临床痴呆评定量表(CDR)、华文认知能力量表(CCAS)进行认知功能评估。QCST-E分别测量12个认知领域:即刻记忆、实物命名、视觉空间、言语流畅性、数字广度、抽象能力、听觉模仿、视觉模仿、动作指令、延迟记忆、简单计算、时空定向,最高总分83分,得分越低,认知功能损害越严重。结果轻度AD组、MCI组、NC组QCST-E总分分别为(51.47±3.91)分、(61.47±2.96)分、(72.60±3.01)分,差异显著(P0.01)。QCST-E各领域和总分与年龄、受教育年限及MMSE、ADL、CCAS得分显著相关(均P0.01)。根据不同文化程度制定QCST-E的划界分,其中QCST-E总分识别MCI与正常老人的总体敏感度为89.6%、特异度为94.5%,曲线下面积(AUC)为0.903(95%CI:0.857~0.963);识别MCI与轻度AD的总体敏感度为81.7%、特异度为88.6%,AUC值为0.898(95%CI:0.845~0.940)。结论老年人快速认知筛查测验内容全面、简便易行,识别MCI的敏感度和特异度良好。
[Abstract]:Objective to evaluate the efficacy of rapid cognitive screening test in the identification of mild cognitive dysfunction (MCI) and early dementia (AD) in the elderly. QCST-EN, MMSE and ADL were used in the rapid cognitive screening test of the elderly. QCST-E was used to measure 12 cognitive domains: immediate memory, physical naming, visual space, speech fluency, number span, abstract ability, auditory imitation. Visual imitation, action instruction, delayed memory, simple calculation, space-time orientation, maximum total score of 83 points, the lower the score, the more serious the cognitive impairment. Results the total score of QCST-E in the NC group of mild AD group was 51.47 卤3.91) and the score was 61.47 卤2.96) and 72.60 卤3.01). The difference was significant (P 0.01). QCST-E scores were significantly correlated with age, years of education and scores of QCST-E (all P 0.01). The demarcation scores of QCST-E were determined according to different education levels. The overall sensitivity, specificity and area under the curve of QCST-E in identifying MCI and normal elderly were 89.6, 94.5and 0.903 / 95CI: 0.857 / 0.963respectively, and the overall sensitivity and specificity of identifying MCI and mild AD were 81.7 and 88.66%, respectively. Conclusion the content of rapid cognitive screening test for the elderly is comprehensive, and the total sensitivity is 81.7% and the specificity is 88.66%. Conclusion the content of the rapid cognitive screening test for the elderly is comprehensive, and the total sensitivity is 81.7% and the specificity is 88.695% 0.89 895 CI: 0.8450.Conclusion the content of the rapid cognitive screening test for the elderly is comprehensive. It is simple and easy to use, and the sensitivity and specificity of MCI recognition are good.
【作者单位】：南京医科大学附属无锡精神卫生中心;
【基金】：无锡市科技发展资金项目(CSE31N1323)
【分类号】：R749.1

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