躯体形式疼痛障碍患者脑灰质体积变化及其与NRS评分的关系

发布时间：2018-03-06 18:35

本文选题：躯体形式疼痛障碍　切入点：核磁共振成像　出处：《山东医药》2017年27期 　论文类型：期刊论文

【摘要】：目的利用基于头颅MRI的体素形态学分析(VBM)技术,观察躯体形式疼痛障碍(SPD)患者脑灰质体积改变,并分析其与疼痛程度的关系。方法选择SPD患者10例纳入病例组、健康志愿者14例纳入对照组。对SPD患者进行疼痛数字评价量表(NRS)评分。两组均行头颅MRI检查,高分辨3D T1WI数据采集,保存图像。将两组头颅MRI检查所获得的所有图像数据进行VBM,测算全脑体积及灰质体积,并获取两组灰质体积差异有统计学意义的脑区。采用Pearson相关分析法分析SPD患者灰质体积与NRS评分的相关性。结果 VBM显示,病例组灰质体积大于对照组(P0.01),灰质体积增加的区域主要位于左侧丘脑。病例组左侧丘脑灰质体积与NRS评分无显著相关性(r=0.631,P0.05)。结论 SPD患者头颅MRI VBM显示脑灰质体积增大,主要位于左侧丘脑;脑灰质体积改变与疼痛程度无明显相关性。
[Abstract]:Objective to observe the changes of brain gray matter volume in patients with somatoform pain disorder (SPD) and to analyze the relationship between the volume of gray matter and the degree of pain by using the technique of morphologic analysis of voxel based on MRI. Methods Ten patients with SPD were selected to be included in the case group. 14 healthy volunteers were included in the control group. The patients with SPD were assessed with digital pain assessment scale (NRS). The head MRI was performed in both groups, and 3D T1WI data acquisition was performed in both groups. Save the image. The whole brain volume and gray matter volume were measured by using VBMs from all the image data obtained from the two groups of cranial MRI. Pearson correlation analysis was used to analyze the correlation between gray matter volume and NRS score in patients with SPD. Results VBM showed that there were significant differences in gray matter volume between the two groups. The gray matter volume in the case group was larger than that in the control group (P 0.01), and the area in which the gray matter volume increased was mainly located in the left thalamus. There was no significant correlation between the left thalamus gray matter volume and the NRS score in the case group. Conclusion the cranial MRI VBM of the patients with SPD shows the increase of the gray matter volume. It was mainly located in the left thalamus, and there was no significant correlation between the changes of gray matter volume and the degree of pain.
【作者单位】：荆门市第一人民医院;长江大学临床医学院长江大学附属第一医院;
【基金】：湖北省教育厅科研项目(B2015441)
【分类号】：R749.2

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