酒精成瘾者静息态缺省模式网络fMRI

发布时间：2018-03-08 05:29

  本文选题：乙醇　切入点：静息态　出处：《中国医学影像技术》2014年08期 　论文类型：期刊论文

【摘要】：目的应用静息态fMRI观察酒精成瘾者缺省模式网络(DMN)改变。方法对30例酒精成瘾者(酒精成瘾组)及30名性别、年龄、受教育程度及尼古丁依赖程度相匹配的健康志愿者(对照组)进行静息态fMRI扫描,采取独立成分分析方法提取DMN,对两组DMN进行统计分析。结果相对于对照组,酒精成瘾组DMN在右楔前叶、左小脑脚Ⅱ区功能连接减低,而在左后扣带回、右颞中回、右颞上回及右楔前叶区域功能连接增强。结论酒精成瘾者DMN功能异常。静息态功能MR成像揭示酒精成瘾复杂神经机制具有一定的价值。
[Abstract]:Objective to observe the changes of default pattern of fMRI in alcohol addicts by resting fMRI. Methods 30 cases of alcohol addicts (alcohol addiction group) and 30 cases of sex and age were studied. Healthy volunteers with matched education and nicotine dependence degree (control group) were scanned with resting fMRI, and DMN was extracted by independent component analysis (ICA). The results were compared with those in control group. In the alcohol addiction group, the functional junctions of DMN in the right anterior cuneate lobe, left cerebellar foot area 鈪，

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