脊髓小脑共济失调1、2、3、12型认知功能损害研究

发布时间：2018-03-08 12:35

本文选题：脊髓小脑共济失调　切入点：认知功能损害　出处：《新疆医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：探讨脊髓小脑共济失调1、2、3、12型患者是否具有认知功能损害。方法：脊髓小脑共济失调（Spino Cerebellar Ataxia，SCA）1、2、3、12型患者23人，正常对照45人（年龄、性别、受教育年限相匹配），采用蒙特利尔认知评估量表（Montreal Cognitive Assessment，MoCA）、简易智能精神状态检查量表（Mini-Mental State Examination，MMSE）筛查患者的整体认知功能。采用一整套认知功能评估量表测试SCA1-3患者的注意功能、语言流畅性、即刻回忆、延迟回忆、视空间与执行能力、逻辑思维能力。采用国际协作共济失调评估量表（ICARS）对患者进行共济失调严重程度评分。采用日常生活能力量表评估研究对象的日常生活能力。采用汉密尔顿抑郁量表评估患者的抑郁情绪。结果：脊髓小脑共济失调1、2、3、12型患者具有不同程度的认知功能损害。SCA1表现在视空间与执行和注意功能，SCA2和SCA3表现在语言流畅性、即刻和延迟回忆、执行功能，，而注意和视空间是不受损的。ICARS评分为11-78分，其中，轻度3例，中度14例，重度4例，特重2例。日常生活能力量表得分是22-66分。结论：本次研究发现注意、视空间与执行、即刻记忆、延迟回忆及语言的流产性功能障碍表现在SCA1-3，而且可能与疾病的严重程度有关，与年龄、发病年龄、受教育年限、病程无关。大多数患者具有抑郁情绪，SCA3比SCA1和SCA2重。
[Abstract]:Objective: To investigate whether spinocerebellar ataxia type 1,2,3,12 patients with cognitive impairment. Methods: spinocerebellar ataxia (Spino Cerebellar Ataxia, SCA 1,2,3,12) in 23 patients, and 45 healthy individuals (age, gender, education matched), the Montreal cognitive assessment scale (Montreal Cognitive Assessment, MoCA), Mini Mental State Examination (Mini-Mental State, Examination, MMSE) overall cognitive function screening patients. Using a set of cognitive function assessment scale attention function test in patients with SCA1-3, language fluency, immediate memory, delayed memory, visuospatial and executive ability, logical thinking ability. The International Cooperative Ataxia assessment table (ICARS) for patients with ataxia severity score. The ADL evaluated the ability of daily life. Hamilton Hamilton Depression Rating Scale depression assessment patients. Results: spinocerebellar ataxia type 1,2,3,12 patients with cognitive impairment in different degree of.SCA1 expression in the visual space and executive function and attention, SCA2 and SCA3 expression in verbal fluency, immediate and delayed recall, executive function, attention and visual space is not damaged the.ICARS score is 11-78 points, including 3 mild cases, 14 moderate cases and 4 severe cases, 2 severe cases. ADL score is 22-66. Conclusion: This study found that attention, visual space and execution, immediate memory, delayed recall abortion sexual dysfunction and language performance in SCA1-3, and may related with the severity of the disease, and the age of onset, age, years of education, the course of business. Most of the patients with depression, SCA3 and SCA2 than SCA1.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1;R744

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