兰索拉唑联合常规治疗对焦虑症患者消化系症状的影响

发布时间：2018-03-09 18:26

本文选题：焦虑症　切入点：胃食管返流　出处：《世界华人消化杂志》2014年26期 　论文类型：期刊论文

【摘要】：目的:探究兰索拉唑联合常规治疗方案对焦虑症患者消化系症状治疗效果.方法:选取2011-01/2014-03来海南省安宁医院就诊的焦虑症合并消化系症状患者118例,依据分层随机分组法将患者分为治疗组及对照组,每组59例;给予对照组常规治疗方案及消化系症状的对症处理进行治疗,治疗组在对照组治疗方案的基础上给予口服兰索拉唑片进行治疗;分别于治疗前及治疗6 wk后食管pH值(esophageal pH,EpH)、食管下端压力(lower esophageal sphincter pressure,LESP)、症状持续时间、大便潜血阳性例数、餐后饱胀、反酸、嗳气及不规则性腹痛例数、不良反应及药物不良反应情况.结果:治疗前两组患者的EpH、LESP、大便潜血阳性例数、餐后饱胀、反酸、嗳气及不规则性腹痛例数比较差异无统计学意义(P0.05);治疗6 wk后治疗组患者EpH(5.68±1.52)及LESP(12.46 mmHg±4.29 mmHg)明显高于对照组(4.98±1.47、9.76 mmHg±3.17mmHg),治疗组患者症状持续时间、大便潜血阳性例数、餐后饱胀、反酸、嗳气及不规则性腹痛例数明显低于对照组,差异有统计学意义(P0.05);治疗过程中治疗组患者出现持续性腹痛、腹泻、贫血及呕血或便血例数明显低于对照组,差异有统计学意义(P0.05).结论:联合应用兰索拉唑可明显减轻患者消化系症状程度及持续时间,降低消化系并发症进展可能.
[Abstract]:Objective: to investigate the therapeutic effect of lansoprazole combined with routine therapy on digestive system symptoms of anxiety patients. Methods: 118 patients with anxiety disorder complicated with digestive system symptoms were selected from 2011-01 / 2014-03 to Hainan Anning Hospital. The patients were divided into treatment group (n = 59) and control group (n = 59). The treatment group was treated with Lansoprazole tablet on the basis of the control group, the esophageal pH value of ephedrine before treatment and 6 weeks after treatment, the lower esophageal pressure lower esophageal sphincter pressureLESPN, the duration of symptoms, and the number of cases with positive occult blood in stool. Postprandial fullness, regurgitation, belching and irregular abdominal pain, adverse reactions and adverse drug reactions. Results: before treatment, the two groups of patients with EpHLESP, stool occult blood positive cases, postprandial fullness, acid regurgitation, There was no significant difference in the number of cases of belching and irregular abdominal pain (P 0.05), EpH(5.68 卤1.52) and LESP(12.46 mmHg 卤4.29 mm Hg in the treatment group were significantly higher than those in the control group (4.98 卤1.47 卤9.76 mmHg 卤3.17 mm HgG) after 6 wk treatment. The duration of symptoms, the number of positive cases of stool occult blood, postprandial fullness, acid regurgitation in the treatment group were significantly higher than those in the control group (4.98 卤1.47 卤9.76 mmHg 卤3.17 mm). The number of cases of belching and irregular abdominal pain was significantly lower than that of the control group (P 0.05), and the cases of persistent abdominal pain, diarrhea, anemia and hematemesis or hematochezia in the treatment group were significantly lower than those in the control group. Conclusion: combined use of lansoprazole can significantly reduce the severity and duration of digestive system symptoms and decrease the progression of digestive complications.
【作者单位】：海南省安宁医院精神科;
【分类号】：R749.72

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