炎症在慢性疼痛与抑郁共病过程中的作用

发布时间：2018-03-10 05:35

本文选题：疼痛　切入点：抑郁　出处：《中国疼痛医学杂志》2014年12期 　论文类型：期刊论文

【摘要】：慢性疼痛和抑郁共病是个非常普遍的问题,但是其机制复杂,其中炎症是这些机制中的关键因素之一,本文综述了慢性疼痛与抑郁共病的炎症机制。这些可能的机制过程包括慢性疼痛是一种长期应激,导致细胞介导的免疫的激活和炎症的产生,继之出现的氧化/硝化应激通路的激活,下丘脑-垂体-肾上腺轴亢进,色氨酸代谢通路的改变,神经元变性等导致与抑郁共病。为慢性疼痛合并抑郁的患者的治疗提供新的理论基础。
[Abstract]:Chronic pain and depression are very common problems, but the mechanisms are complex, and inflammation is one of the key factors in these mechanisms. This review reviews the inflammatory mechanisms of chronic pain and depression. These possible mechanisms include chronic pain as a long-term stress that leads to cellular mediated immune activation and inflammation. Followed by the activation of oxidative / nitrifying stress pathways, hyperactivity of hypothalamus-pituitary-adrenal axis, changes in tryptophan metabolic pathways, Neuronal degeneration, which leads to syndromes with depression, provides a new theoretical basis for the treatment of patients with chronic pain and depression.
【作者单位】：来宾市中医院麻醉与疼痛科;广西民族医院内科;广西中医药大学第一附属医院脑病科;
【分类号】：R402;R749.4

【共引文献】