长期使用喹硫平对阿尔茨海默病患者认知功能的影响

发布时间：2018-03-13 10:39

本文选题：阿尔茨海默病　切入点：喹硫平　出处：《上海交通大学学报(医学版)》2014年02期 　论文类型：期刊论文

【摘要】：目的探讨长期使用喹硫平治疗对阿尔茨海默病(AD)患者认知功能的影响。方法纳入51例伴有精神行为症状的门诊AD患者,随机分为治疗组(服用喹硫平,n=26)和对照组(未服用喹硫平,n=25)。分别于治疗前(基线)、治疗3个月和6个月时采用认知能力筛查量表(CASI)和老年性痴呆评定量表认知分量表(ADAS-cog)评估两组患者的认知功能。结果两组AD患者的CASI和ADAS-cog基线评分比较差异无统计学意义(P0.05);3个月后,两组的CASI和ADAS-cog评分均有所提高,但差异无统计学意义(P0.05);6个月后,两组的CASI及ADAS-cog评分进一步提高,其中治疗组的ADAS-cog评分显著高于对照组,差异有统计学意义(P0.05)。结论长期使用喹硫平治疗可能对AD患者的认知功能产生不利影响。
[Abstract]:Objective to investigate the effect of long-term treatment of quintiapine on cognitive function in patients with Alzheimer's disease (AD). They were randomly divided into two groups: the treatment group (taking quinolipin 26) and the control group (without quinolipin). Before the treatment (baseline, 3 and 6 months), the cognitive ability screening scale (CASII) and the cognitive score of the Alzheimer's disease rating scale (Alzheimer's disease rating scale) were used respectively before treatment (baseline, 3 months and 6 months). Results there was no significant difference in the baseline scores of CASI and ADAS-cog between the two groups (P 0.05), and after 3 months, there was no significant difference between the two groups. The CASI and ADAS-cog scores of the two groups were improved, but there was no significant difference between the two groups (P 0.05). After 6 months, the CASI and ADAS-cog scores of the two groups were further improved, and the ADAS-cog score of the treatment group was significantly higher than that of the control group. Conclusion Long-term treatment with quetiapine may have adverse effects on cognitive function of AD patients.
【作者单位】：上海交通大学医学院附属精神卫生中心;
【基金】：上海市卫生局基金(2010007)~~
【分类号】：R749.16

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