单相抑郁症患者脑磁共振弥散张量成像FA值变化及意义

发布时间：2018-03-13 12:00

本文选题：单相抑郁症　切入点：弥散张量成像　出处：《山东医药》2015年47期 　论文类型：期刊论文

【摘要】：目的观察单相抑郁症患者脑磁共振弥散张量成像(DTI)各向异性分数(FA)值变化,并探讨其意义。方法采集21例单相抑郁症患者(单相抑郁症组)及与之匹配健康对照组的DTI图像,对计算得出的全脑FA值使用基于体素的方法进行统计分析,对得到的感兴趣区域进行提取,并与心理学量表测试结果做相关性分析。结果单相抑郁症组右侧壳核,右侧楔前叶、边缘叶、扣带回,左侧三角部额下回,左侧枕中回脑区FA值分别为0.205±0.024、0.336±0.053、0.228±0.068、0.308±0.073,健康对照组分别为0.228±0.019、0.391±0.052、0.281±0.045、0.356±0.075,两组比较,P均0.05。两组右侧壳核FA值与QIDS-SR评分(r=-0.353,P=0.022),右侧楔前叶、边缘叶、扣带回FA值与PHQ-9评分(r=-0.404,P=0.008)及QIDS-SR评分(r=-0.315,P=0.043),左侧枕中回FA值与T-AI评分(r=-0.353,P=0.022)均呈负相关。结论单相抑郁症患者右侧壳核,右侧楔前叶、边缘叶、扣带回,左侧三角部额下回,左侧枕中回脑区的FA值降低,表明单相抑郁症患者存在多个脑区白质微结构的变化,这些变化可能与抑郁或焦虑情绪障碍有关。
[Abstract]:Objective to observe the changes of anisotropic fraction (FAA) of Mr diffusion Zhang Liang imaging (DTI) in patients with monophasic depression and to explore its significance. Methods DTI images of 21 patients with monophasic depression (monophasic depression group) and matched healthy controls were collected. The calculated FA values of the whole brain were statistically analyzed by voxel based method, and the regions of interest were extracted and correlated with the results of psychological scale. Results the right putamen nucleus and the right anterior wedge of monophasic depression group were analyzed. The FA values of marginal lobe, cingulate gyrus, inferior frontal gyrus of left triangular part and left middle occipital gyrus were 0.205 卤0.024 卤0.336 卤0.053 and 0.228 卤0.068 卤0.308 卤0.073, respectively, and those of healthy control group were 0.228 卤0.019 卤0.052 卤0.281 卤0.045 0.356 卤0.075 respectively. There was a negative correlation between FA value of cingulate gyrus and PHQ-9 score (r = 0.404) and QIDS-SR score (P = 0.043) and left middle occipital gyrus (FA) and T-AI score (n = 0.353). Conclusion in patients with monophasic depression, the right putamen, right anterior cuneate lobe, marginal lobe, cingulate gyrus, inferior frontal gyrus of left triangle, and left triangular inferior frontal gyrus are negatively correlated. The decrease of FA in left middle occipital gyrus suggests that there are many changes in white matter microstructure in monophasic depression which may be related to depression or anxiety disorder.
【作者单位】：北京工业大学国际WIC研究院;磁共振成像脑信息学北京市重点实验室;脑信息智慧服务北京市国际科技合作基地;前桥工业大学生命科学与信息工程系;
【基金】：国家国际科技合作专项(2013DFA32180)
【分类号】：R749.4;R445.2

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