精神分裂症影响因素的病例对照研究

发布时间：2018-03-14 00:34

本文选题：精神分裂症　切入点：影响因素　出处：《苏州大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的了解苏州市吴江区震泽镇辖区内的精神分裂症的主要影响因素，为进一步探讨精神分裂症病因和制定应对精神分裂症的策略和措施提供依据。方法以苏州市吴江区震泽镇辖区2012年管理全部249例精神分裂症患者为病例组，以按性别、年龄（±5岁）、居住地（同一居委会）进行1：1匹配的非精神疾病病人为对照组，对13项精神分裂症的可疑影响因素等，进行回顾性问卷调查。本次调查由研究者一人负责，调查对象病例组为患者的监护人、对照组由患者本人。经当场和当天审核合格所获得资料采用EpiData3.1软件“双人双次录入并进行逻辑纠错”的方法进行数据库建立和SPSS20.0统计软件采用单因素条件Logistic回归分析方法和多因素条件Logistic回归分析后退法进行统计分析。结果 249对配对资料无一剔除，全部合格。病例组与对照组在性别、年龄、居住地方面无统计学差异(P0.05)。病例组和对照组重复调查符合率无统计学差异(P0.05) 单因素分析结果表明，有精神病家族史（OR=6.257）、性格内向（OR=5.506）、不恰当情绪宣泄（OR=3.476）、遭遇精神创伤事件（OR=3.435）、无知心朋友（OR=3.354）、单身（OR=2.784）、幼年不良遭遇（OR=2.658）、文化程度低（OR=2.625）、家庭成员关系对抗（OR=2.363）可能是精神分裂症促进因素；而成年前父母非在婚（OR=1.052）、不与家人共同居住（OR=1.198）、家庭经济状况（OR=1.283）、有颅脑疾病史（OR=1.675）可能是精神分裂症的无关因素。多因素分析结果表明，，有精神病家族史（OR=4.623）、遭遇精神创伤事件（OR=3.435）、无知心朋友（OR=3.096）、性格内向（OR=2.752）、不恰当情绪宣泄（OR=1.771）可能是促进因素。结论 1、精神病家族史阳性、遭遇精神创伤事件、人际关系不良、不善情绪宣泄、性格内向等内外环境因素可能是苏州市吴江区震泽镇精神分裂症的主要促进因素。应将具有这些特征的人群作为精神分裂症的高危人群进行预防。 2、幼年不良遭遇、家庭成员关系对抗、文化程度低、单身等内外环境因素与精神分裂症是否是苏州市吴江区震泽镇精神分裂症可能的促进因素有待于进一步研究证实。 3、家庭经济状况、共同居住者、颅脑疾病史可能与苏州市吴江区震泽镇精神分裂症无关。
[Abstract]:Purpose. To understand the main influencing factors of schizophrenia in Zhenze Town, Wu Jiang District, Suzhou City, and to provide the basis for further discussion on the etiology of schizophrenia and the formulation of strategies and measures to deal with it. Method. In 2012, all 249 schizophrenic patients in Zhenze Town District, Wu Jiang District, Suzhou were taken as the case group, and 1: 1 matched non-mental disease patients who were matched by sex, age (卤5 years old) and residence (the same neighborhood committee) were taken as the control group. A retrospective questionnaire survey was conducted on 13 suspected factors affecting schizophrenia. The patient group was the guardian of the patient and the control group was the patient himself. The data obtained after the spot and on the day examination were established by the method of EpiData3.1 software "double entry and logical error correction" and the single factor conditional Logistic regression analysis method and multiple factors were used in the SPSS20.0 statistical software. The regression analysis of conditional Logistic regression was carried out. Results. There was no significant difference in sex, age and residence between the case group and the control group (P 0.05). There was no significant difference in the coincidence rate of repeated investigation between the case group and the control group (P 0.05). The results of single factor analysis show that, The family history of mental illness is 6.257, the personality is introverted, OR5.506, the inappropriate emotional catharsis is 3.476, the mental trauma event is 3.435, no close friend is OR3.354, the single person is 2.784, the education level is lower than OR2.625, the family member relationship is antagonistic to OR2.363) may be the promoting factor of schizophrenia. Before adulthood, parents were not married at OR1. 052, did not live with their families, and their economic status was 1.283. History of craniocerebral disease was 1. 675) and may be an unrelated factor for schizophrenia. The results of multivariate analysis showed that the family history of mental illness was 4.623, the occurrence of mental trauma was 3.435, no intimate friend was 3.096, and the personality was introverted, and the inappropriate emotional catharsis was OR1.771). Conclusion. 1. Positive family history of mental illness, traumatic events, poor interpersonal relationships, and poor emotional release. Introversion and other internal and external environmental factors may be the main promoting factors of schizophrenia in Zhenze Town, Wu Jiang District, Suzhou City. The population with these characteristics should be regarded as the high risk group of schizophrenia. 2.The adverse experiences of childhood, family relationship confrontation, low level of education, singleness and so on, and whether schizophrenia is the possible promoting factor of schizophrenia in Zhenze Town, Wu Jiang District of Suzhou should be further studied and verified. 3. Family economic status, cohabitation, history of craniocerebral disease may have nothing to do with schizophrenia in Zhenze Town, Wu Jiang District, Suzhou City.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.3

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