阿立哌唑与奥氮平对精神分裂症患者血糖、血脂影响的Meta分析

发布时间：2018-03-19 02:34

本文选题：阿立哌唑　切入点：奥氮平　出处：《中国现代医学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的利用Meta分析的方法评估阿立哌唑与奥氮平对精神分裂症患者血糖、血脂的差异。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Pub Med、Elsevier、Cochrane Library等并手工检索杂志、书籍等相关资料,检索时间为2011年1月1日-2015年7月31日,对有关阿立哌唑与奥氮平治疗精神分裂症患者的随机对照研究资料进行全面收集,在质量评价的基础上,利用Rev Man 5.2软件进行Meta分析。结果共纳入9篇随机对照研究(915例患者)进行Meta分析,结果显示,干预结束后服用奥氮平的精神分裂症患者空腹血糖要高于阿立哌唑组[MD=-0.37,95%CI(-0.53,-0.21)],差异有统计学意义(P=0.000);干预结束后奥氮平组的血三酰甘油水平要高于阿立哌唑组[MD=-0.22,95%CI(-0.29,-0.15)],差异有统计学意义(P=0.000);干预结束后服用奥氮平组的血胆固醇水平要高于阿立哌唑组[MD=-0.42,95%CI(-0.54,-0.29)],差异有统计学意义(P=0.000)。结论奥氮平较阿立哌唑更易引起精神分裂症患者血糖、血脂紊乱。
[Abstract]:Objective to evaluate the effects of aripiprazole and olanzapine on blood glucose and blood lipid in schizophrenic patients by Meta analysis. The Chinese Biomedical Literature Database, Pub Med#en0#, Elsevier, Cochrane Library, et al., and manually searched magazines, books and other related materials from January 1st 2011 to July 31st 2015. The data of randomized controlled study of aripiprazole and olanzapine in the treatment of schizophrenia were collected. Meta analysis was carried out with Rev Man 5.2 software. Results Meta analysis was carried out in 915 patients in 9 randomized controlled studies. The results showed that, The fasting blood glucose of schizophrenia patients taking olanzapine after intervention was higher than that of aripiprazole group [MD-0.37CI-0.53CI-0.21], the difference was statistically significant, and the serum triglyceride level of olanzapine group was higher than that of aripiprazole group [MD-0.2295CI-0.29CI-0.15] after the intervention. After the intervention, the serum cholesterol level of olanzapine group was higher than that of aripiprazole group [MD-0.42CI-0.54CI-0.29], and the difference was statistically significant. Conclusion olanzapine is more likely to cause blood sugar in schizophrenia patients than aripiprazole. Dyslipidemia.
【作者单位】：南昌大学第一附属医院心身科;南昌大学第一附属医院康复科;
【基金】：江西省研究生创新项目(No:YC2015-S095)
【分类号】：R749.3

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