帕罗西汀治疗慢性阻塞性肺疾病患者焦虑和抑郁的疗效分析

发布时间：2018-03-19 03:04

本文选题：肺疾病　切入点：慢性肺阻塞性　出处：《中国全科医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的了解帕罗西汀对慢性阻塞性肺疾病(COPD)患者焦虑、抑郁的疗效。方法选取2015年10月—2016年10月于浙江省瑞安市人民医院呼吸内科就诊的COPD患者100例为研究对象。采用随机数字表法将患者随机分为常规组和研究组,各50例。常规组给予噻托溴铵,研究组联合帕罗西汀治疗。比较两组患者治疗前后肺功能、运动耐量及汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分。结果常规组与研究组治疗后第1秒用力呼气量(FEV1)、第1秒用力呼气量/呼气容积(FEV1/FVC)、深吸气量(IC)、6 min步行距离(6MWD)比较,差异无统计学意义(P0.05);研究组HAMA、HAMD评分低于常规组,差异有统计学意义(P0.05)。结论针对COPD存在焦虑、抑郁患者给予帕罗西汀联合噻托溴铵治疗可有效改善抑郁、焦虑情况,并对肺功能治疗无影响。
[Abstract]:Objective to investigate the anxiety of paroxetine in patients with chronic obstructive pulmonary disease (COPD). Methods from October 2015 to October 2016, 100 patients with COPD in Department of Respiratory, Renmin Hospital of Ruian City, Zhejiang Province, were selected as study subjects. The patients were randomly divided into two groups: routine group and study group. 50 cases each. The routine group was given tiotropium bromide and the study group was treated with paroxetine. The pulmonary function of the two groups was compared before and after treatment. Results the scores of exercise tolerance and Hamilton anxiety scale (Hama) and Hamilton Depression scale (Hamd) were compared between the routine group and the study group at 1 seconds forced expiratory volume (FEV1), 1 seconds forced expiratory volume / expiratory volume (FEV1 / FVCV), deep inspiratory volume and 6 min walking distance (6MWD). There was no significant difference between the two groups (P 0.05), the Hama Hamd score in the study group was lower than that in the routine group, and the difference was statistically significant (P 0.05). Conclusion there is anxiety in patients with COPD, and the treatment of paroxetine combined with tiotropium bromide can effectively improve the depression and anxiety. There was no effect on the treatment of lung function.
【作者单位】：浙江省瑞安市人民医院呼吸内科;
【分类号】：R563.9;R749

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