中西医结合治疗创伤后应激障碍240例临床研究

发布时间：2018-03-21 20:02

本文选题：创伤后应激障碍　切入点：糖郁疏　出处：《中国中医基础医学杂志》2014年02期 　论文类型：期刊论文

【摘要】：目的:观察糖郁疏联合帕罗西汀治疗创伤后应激障碍的临床疗效及安全性。方法:将240例创伤后应激障碍患者随机分为治疗组和对照组,治疗组给予糖郁疏免煎制剂治疗,每日1剂分3次口服,同时服用帕罗西汀片每次20 mg,每日1次口服,对照组服用帕罗西汀片用法同上,治疗持续12周,均采用创伤后应激障碍自评量表(PTSD-SS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)进行评估。结果:治疗后2组PTSD-SS量表评分总有效率治疗组为89%,对照组72%,经Ridit分析差异有统计学意义(P0.05)。经重复测量资料的方差分析,治疗组治疗后相应不同时期均优于对照组,2组比较差异有统计学意义(P0.05)。治疗组不良反应低于对照组,不良事件发生率经χ2检验比较有统计学意义(P0.05)。结论:糖郁疏联合帕罗西汀治疗创伤后应激障碍的临床疗效与西药帕罗西汀比较,具有起效快、撤药后减少其症状复发、减少帕罗西汀的不良反应的优势,联合用药的不良反应低于西药帕罗西汀。
[Abstract]:Objective: to observe the clinical efficacy and safety of Tangyu Shu combined with paroxetine in the treatment of post-traumatic stress disorder. Methods: 240 patients with post-traumatic stress disorder were randomly divided into treatment group and control group. One dose of paroxetine was given 3 times a day, and 20 mg of paroxetine was taken at the same time, while the control group was given paroxetine tablets for 12 weeks. All of them were evaluated with PTSD SSN, Hamilton Depression scale (Hamd) and Hamilton anxiety scale (Hama). Results: after treatment, the total effective rate of PTSD-SS scale in treatment group was 89 and that in control group was 72.The difference was analyzed by Ridit. The variance analysis of repeated measurement data, The treatment group was better than the control group in different periods after treatment, the difference was statistically significant (P 0.05), and the adverse reaction in the treatment group was lower than that in the control group. The incidence of adverse events was statistically significant (P 0.05) by 蠂 2 test. Conclusion: the clinical effect of Tangyu combined with paroxetine in the treatment of post-traumatic stress disorder is faster than that of western drug paroxetine. The advantage of reducing adverse reactions of paroxetine was lower than that of western drug paroxetine.
【作者单位】：成都中医药大学;成都中医药大学附属医院;
【分类号】：R749.5

【参考文献】