滋水清肝颗粒配合心理咨询治疗抑郁症临床观察

发布时间：2018-03-24 02:26

本文选题：抑郁症　切入点：肝郁肾虚证　出处：《长春中医药大学》2012年硕士论文

【摘要】：目的：观察具有滋养阴精，补益肝肾的滋水清肝颗粒，对抑郁症肝郁肾虚型患者中医证候改善的临床疗效、汉密尔顿抑郁量表（HAMD）评分疗效，并对其治疗的整体有效性作出客观的评价分析。方法：任意选择符合纳入标准的门诊抑郁症患者48例，随机分为两组分别为治疗组、对照组。对照组选用口服路优泰，治疗组药物为滋水清肝颗粒，两组均以12周为1个疗程，并同时配合心理咨询每周一次，共12次。试验期间，，停用影响临床疗效的其他中西医药物。观察比较两组药物治疗抑郁症肝郁肾虚型患者的疗效。结果：根据汉密尔顿抑郁量表（HAMD）疗效分析，治疗组临床控制率为67%，总有效率为96%；对照组临床控制率为50%，总有效率为92%；在总有效率方面，治疗组比较对照组，P0.05结果无统计学差异。治疗组和对照组在治疗前后两组患者HAMD积分比较上，P0.05有统计学意义，组间比较P0.05无统计学意义。说明治疗组和对照组治疗前后两组患者HAMD积分无显著差异。治疗组中医症状临床控制率为65%，总有效率为92%；对照组临床控制率为38%，总有效率为83%；总有效率治疗组与对照组有统计学差异P0.05。治疗组及对照组组内和组间比较，治疗前后差异均有统计学意义P0.05；治疗后的组间比较，在神情抑郁，兴趣索然，思维迟缓，健忘，少寐，多梦，腰膝酸软方面，治疗组与对照组差异有统计学意义P0.05，说明在改善以上症状上，治疗组疗效优于对照组。结论：在同样配合12次心理咨询的情况下，治疗组、对照组在治疗肝郁肾虚型抑郁症患者在临床总疗效上无显著性差异，治疗组在中医证候疗效积分上于对照组比较，有显著差异。因此得出滋水清肝颗粒是治疗抑郁症肾虚肝郁证的有效方剂。
[Abstract]:Objective: to observe the clinical effect of Zishuiqinggan granule with nourishing yin and essence and tonifying liver and kidney on the improvement of TCM syndromes in patients with depression of liver stagnation and kidney deficiency, and to evaluate the efficacy of Hamilton Depression scale (Hamd). And the overall effectiveness of its treatment to make an objective evaluation and analysis. Methods: Forty-eight depressive patients who met the inclusion criteria were randomly divided into two groups: treatment group and control group. The control group was treated by oral administration of Luyou Tai, and the treatment group was treated with Zishui Qinggan granule. Both groups were treated with 12 weeks as a course of treatment, and at the same time with psychological counseling once a week, a total of 12 times. During the trial, other traditional Chinese and western medicine affecting the clinical efficacy were stopped. The therapeutic effects of the two groups on depression patients with liver depression and kidney deficiency were observed and compared. Results: according to the analysis of Hamilton Depression scale (Hamd), the clinical control rate and the total effective rate in the treatment group were 67 and 96 respectively; in the control group, the clinical control rate was 50 and the total effective rate was 92; in the total effective rate, the clinical control rate was 50 and the total effective rate was 92. There was no statistical difference between the treatment group and the control group (P0.05). The HAMD scores of the treatment group and the control group before and after treatment were significantly higher than that of the control group (P0.05). There was no significant difference in HAMD scores between the two groups before and after treatment. The clinical control rate of TCM was 65, the total effective rate was 92 in the treatment group, and the clinical control rate in the control group was 38. The total effective rate in the treatment group was significantly different from that in the control group (P 0.05). The differences before and after treatment were statistically significant (P0.05). After treatment, there were significant differences between the two groups in terms of depression, lack of interest, slow thinking, amnesia, sleepless sleep, more dreams, weak waist and knee, The difference between the treatment group and the control group was statistically significant (P 0.05), which indicated that the treatment group was better than the control group in improving the above symptoms. Conclusion: there is no significant difference in the total clinical efficacy between the treatment group and the control group in the treatment of depression due to liver depression and kidney deficiency under the same condition of 12 times of psychological consultation, while the curative effect integral of TCM syndrome in the treatment group is compared with that in the control group, and there is no significant difference in the total clinical effect between the treatment group and the control group. It is concluded that Zishui Qinggan granule is an effective prescription for the treatment of depression with kidney deficiency and liver depression.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.4

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