中国度洛西汀与其他抗抑郁药治疗躯体形式疼痛障碍对照研究的Meta分析

发布时间：2018-03-24 04:39

本文选题：度洛西汀　切入点：抗抑郁药　出处：《中国新药与临床杂志》2015年10期

【摘要】：目的评价在中国度洛西汀治疗躯体形式疼痛障碍的疗效和安全性。方法检索相关期刊论文、万方数据库中度洛西汀与其他抗抑郁药治疗躯体形式疼痛障碍的对照研究(截止到2014年12月)。以Jadad法对纳入文献进行质量评价,采用Review Manager 4.2软件进行Meta分析。结果共检索到相关论文26篇,实际纳入分析11篇,所有研究均未提及分配隐匿和盲法。累计病例数为704例,其中度洛西汀374例,其他抗抑郁药330例。度洛西汀治疗前后组内比较,标化平均效应d=-2.79,95%CI-3.28~-2.29,有非常显著差异(Z=11.04,P0.01);度洛西汀与其他抗抑郁药治疗后组间比较,d=-0.70,95%CI-1.51~0.12,无显著差异(Z=1.67,P0.05)。两组不良反应发生率无显著差异(χ2=1.74,P0.05)。结论度洛西汀与其他抗抑郁药在中国治疗躯体形式疼痛障碍的临床疗效相当。
[Abstract]:Objective to evaluate the efficacy and safety of doxetine in the treatment of somatoform pain disorders in China. A comparative study of doloxetine and other antidepressants in the Wanfang database for the treatment of somatoform pain disorders (as of December 2014). The quality of the included literature was evaluated by Jadad. Meta analysis was carried out with Review Manager 4.2 software. Results A total of 26 papers were retrieved, 11 of which were actually included in the analysis. All the studies did not mention the distributive occult and blind methods. The cumulative number of cases was 704, including 374 cases of doloxetine. Comparison of other antidepressants in 330 patients before and after Doxetine treatment, There was a very significant difference between the two groups in the incidence of adverse reactions (蠂 2, 1.74, P 0.05). Conclusion Doxetine and other antidepressants were compared with other antidepressants after treatment, and there was no significant difference in the incidence of adverse reactions between the two groups (蠂 2, 1.74, P 0.05. Conclusion Doxetine and other antidepressants were compared with other antidepressants in the treatment of Doxicetine and other antidepressants), and there was no significant difference in the incidence of adverse reactions between the two groups (蠂 2, 1.74, P 0.05). The clinical efficacy of the treatment of somatoform pain disorders in China is comparable.
【作者单位】：上饶市第三人民医院;
【分类号】：R749.4

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