5-HTTLPR基因多态性与脑卒中后抑郁关系的meta分析

发布时间：2018-03-24 18:19

本文选题：-HTTLPR　切入点：基因多态性　出处：《郑州大学学报(医学版)》2014年06期

【摘要】：目的:探讨五羟色胺转运体基因启动子区域(5-HTTLPR)基因多态性与脑卒中后抑郁(PSD)的关系。方法:通过Review Manager 5.2软件对筛选出的6项国内外有关5-HTTLPR基因多态性与PSD关系的文献进行综合评价,分别从基因型和等位基因两个方面进行分析,并进行异质性检验、合并效应量分析。结果:各研究间基因型及等位基因的检验结果均无异质性(I2=0%,P0.05)。合并效应量:L/L基因型OR(95%CI)=0.53(0.37~0.76),综合检验Z=3.47,P0.001;S/S基因型OR(95%CI)=2.19(1.66~2.89),综合检验Z=5.54,P0.001;S/L基因型OR(95%CI)=0.67(0.51~0.88),综合检验Z=2.84,P=0.005;L等位基因OR(95%CI)=0.55(0.45~0.67),综合检验Z=5.83,P0.001;S等位基因OR(95%CI)=1.81(1.48~2.21),综合检验Z=5.83,P0.001。结论:5-HTTLPR基因多态性中S/S基因型及S等位基因可能是患PSD的危险因素,L/L、S/L和L等位基因可能是保护性因素。
[Abstract]:Objective: to investigate the relationship between serotonin transporter gene promoter region (5-HTTLPRR) polymorphism and post stroke depression (PSD). Methods: the relationship between 5-HTTLPR gene polymorphism and PSD was analyzed by Review Manager 5.2 software. Comprehensive evaluation of the literature, Genotypes and alleles were analyzed, and heterogeneity tests were performed. Results: there was no heterogeneity in genotypes and alleles tested among the studies. The combined effect was 0.530.370.76% of the L / L genotype OR95CIN, and the comprehensive test of the ZH3.47 P0.001SP-0.001S genotype OR95CIV 2.191.662.89, the combined test of ZH5.54P0.001S- / L genotype OR95CIN 0.670.510.88, and the comprehensive test of ZH2.84P0.001S- / L genotype OR95CIN 0.670.510.88. Because of 0.55 / 0.55 / 0.45 / 0.67 / 0.67 / 0.55 / 0.55 / 0.45 / 0.67, a comprehensive test was made on the allele ORY95CIN 1.81 / 1.48 / 2.21. Conclusion the S- / S genotype and S allele of the 5-HTTLPR gene polymorphism may be the risk factors of PSD and the L / L alleles may be the protective factors of the PSD allele LP / LN / S / L / L alleles may be the protective factors of the alleles L / L and L alleles, which may be the protective factors in the polymorphism of the 5-HTTLPR gene.
【作者单位】：同济大学附属第十人民医院神经内科;上海交通大学附属仁济医院神经内科;
【基金】：国家自然科学基金资助项目010212036
【分类号】：R743.3;R749.4

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