肌肽对皮层下缺血性血管性痴呆动物认知功能的保护作用

发布时间：2018-03-25 00:08

本文选题：肌肽　切入点：认知功能　出处：《中国药理学通报》2014年04期

【摘要】：目的探讨肌肽对皮层下缺血性血管性痴呆动物的认知功能的作用。方法永久性结扎小鼠单侧颈总动脉建立皮层下缺血性血管性痴呆模型后饲养28 d,期间隔天给予肌肽(200、500、750 mg·kg-1)或生理盐水,采用运动量监测、敞箱实验、热板实验,恐惧记忆、水迷宫模型检测小鼠行为学指标。结果与假手术组相比,手术组动物的运动量和疼痛阈值没有改变;其中肌肽(200、500 mg·kg-1)能明显延长小鼠在敞箱实验中的探索时间,逆转手术引起的动物恐惧记忆中背景记忆能力的下降,并明显改善手术引起的水迷宫实验中动物的学习记忆能力的下降。结论单侧颈总动脉结扎所致的皮层下缺血性血管性痴呆会导致认知功能障碍,肌肽对皮层下缺血性血管性痴呆动物的认知功能有明显的保护作用。
[Abstract]:Objective to investigate the effect of carnosine on cognitive function of subcortical ischemic vascular dementia (SVD) in mice. Methods permanent ligation of unilateral common carotid artery was used to establish subcortical ischemic vascular dementia model in mice for 28 days. Carnosine 200500750 mg kg-1) or normal saline, Exercise volume monitoring, open box test, hot plate test, fear memory, water maze model were used to detect the behavioral indexes of mice. Results compared with the sham operation group, the exercise volume and the pain threshold of the operation group did not change. Carnosine 200500 mg kg-1) could significantly prolong the exploration time of mice in open box experiment and reverse the decline of background memory in fear memory induced by surgery. It can obviously improve the ability of learning and memory in the water maze experiment. Conclusion the subcortical ischemic vascular dementia caused by unilateral common carotid artery ligation may lead to cognitive impairment. Carnosine has obvious protective effect on cognitive function of subcortical ischemic vascular dementia.
【作者单位】：上海交通大学医学院附属新华医院药学部;浙江大学医学院;
【基金】：国家杰出青年科学基金资助项目(No 304725047) 国家重点基础研究发展计划(973计划资助项目)(No 2011CB504403) 国家自然科学基金资助项目(No 81030061,81273490)
【分类号】：R749.16

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