帕利哌酮治疗精神分裂症的血药浓度与临床疗效研究

发布时间：2018-03-25 00:32

本文选题：精神分裂症　切入点：治疗药物监测　出处：《中国现代医学杂志》2017年04期

【摘要】：目的探讨帕利哌酮治疗精神分裂症的血药浓度与剂量、临床疗效及副反应的关系。方法采用超高效液相色谱串联质谱法分别于治疗后1、2及4周末检测精神分裂症患者体内帕利哌酮血药浓度;于基线期、治疗后1、2及4周末采用阳性与阴性症状量表(PANSS)评定疗效,治疗时出现的症状量表(TESS)评定副反应;于基线期和治疗后4周末行血常规、尿常规、肝肾功能、心电图及泌乳素检查。结果治疗后1、2及4周末的服药剂量分别为(7.24±1.50),(8.89±1.29)和(9.63±1.77),与相应时间的血药浓度(18.64±7.93),(25.44±10.71)和(27.65±13.89)呈正相关(P0.05);帕利哌酮血药浓度(30.91±17.99)与女性患者的血清泌乳素(117.9±50.66)相关(P0.05);未发现帕利哌酮血药浓度与PANSS减分率、TESS量表以及体重增加值相关(P0.05);有效组与无效组间、出现锥外系反应组患者与未出现锥外系反应组间血药浓度比较差异皆均无统计学意义(P0.05)。结论帕利哌酮的血药浓度可能与服药剂量呈非线性正相关;帕利哌酮的血药浓度与女性患者的血清泌乳素水平呈正相关。
[Abstract]:Objective to investigate the plasma concentration and dose of parpipraxone in the treatment of schizophrenia. Methods the plasma concentration of Paripiperone in schizophrenic patients was detected at the end of 2 and 4 weeks after treatment by ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS). Positive and negative symptom scale (PANSS) was used to evaluate the curative effect and the symptom scale (TESS) was used to evaluate the side effects at the 2nd and 4th week after treatment, and blood routine examination, urine routine examination, liver and kidney function were performed at baseline and 4 weeks after treatment. Electrocardiogram and prolactin examination. Results at the end of 1, 2 and 4 weeks after treatment, the dose of Paripidone was 8.89 卤1.29) and 9.63 卤1.77, respectively, which was positively correlated with the serum drug concentrations (18.64 卤7.93) 25.44 卤10.71) and 27.65 卤13.89 (P 0.05), and the serum prolactin concentration of female patients was 117.9 卤50.66). There was no correlation between plasma concentration of Parioperazone and PANSS score reduction rate (Tess) and weight gain (P 0.05); between the effective group and the ineffective group, there was no correlation between the effective group and the ineffective group. There was no significant difference in blood drug concentration between patients with and without extrapyramidal reaction (P 0.05). Conclusion there may be a nonlinear positive correlation between the plasma concentration of parpiperazone and the dosage of the drug. There was a positive correlation between serum prolactin level and serum concentration of parpipraxone in female patients.
【作者单位】：昆明医科大学第一附属医院精神科;
【分类号】：R749.3

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