不同戒断期毒品戒断者对金钱奖赏敏感性的ERP研究

发布时间：2018-03-30 15:02

本文选题：毒品成瘾　切入点：戒断期　出处：《中国临床心理学杂志》2014年04期

【摘要】：目的:本研究采用金钱奖赏范式探讨不同戒断时长(短期戒断组:平均2.7个月,中期戒断组:平均19.36个月,长期戒断组:平均49.6个月)的毒品戒断者与正常匹配组,在分辨不同额度的金钱奖赏时认知加工能力的损伤和恢复情况。方法:研究中要求被试在三种不同的奖赏条件(45分,1分,0分)下完成Go/No-go任务。结果:脑电结果表明,对不同额度的金钱奖赏加工时,短期戒断组和中期戒断组的脑区功能受损,表现为其诱发的N2和P3波幅在三种条件下差异都不显著;长期戒断组在奖赏条件下诱发的N2和P3平均波幅显著大于0分条件,但是波幅差异的程度显著低于控制组。结论:长期戒断组和控制组在神经激活模式上存在的差异,表明经过三年以上的戒断后,戒毒人员的脑功能显示出一定水平的恢复,但是仍未恢复至正常水平。
[Abstract]:Objective: to explore the matching between drug abstinents and normal subjects with different abstinence periods (short withdrawal group: average 2.7 months, metaphase withdrawal group: mean 19.36 months, long-term withdrawal group: average 49.6 months) using money reward paradigm.Cognitive processing impairment and recovery in identifying different amounts of monetary reward.Methods: subjects were asked to complete the Go/No-go task under three different reward conditions (45, 1, 0).Results: the results of EEG showed that the brain function of short-term withdrawal group and metaphase withdrawal group were damaged when different amount of money reward was processed. The results showed that the amplitude of N2 and P3 induced by EEG were not significantly different under the three conditions.The N _ 2 and P _ 3 mean amplitude induced by the reward condition in the long-term abstinence group was significantly higher than that in the control group, but the amplitude difference was significantly lower than that in the control group.Conclusion: there are differences in the neural activation pattern between the long-term abstinence group and the control group, which indicates that after more than three years of abstinence, the brain function of the drug addicts shows a certain level of recovery, but has not returned to the normal level.
【作者单位】：北京师范大学心理学院应用实验心理北京市重点实验室;北京师范大学认知神经科学与学习国家重点实验室和麦戈文脑科学研究院;北京师范大学情绪调节研究中心;脑与学习协同创新中心;北京市天堂河戒毒康复所;
【基金】：国家社科基金重大项目(11&ZD187) 北京市教育委员会共建项目建设计划(403101) 尚善基金的资助
【分类号】：R749.64

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