首次诊断双相障碍患者的生存分析

发布时间：2018-03-31 01:37

本文选题：双相障碍　切入点：抗精神病药物治疗　出处：《上海交通大学学报(医学版)》2014年04期

【摘要】：目的分析首次诊断双相障碍并接受药物治疗患者的生存情况及其影响因素。方法收集785例首次诊断双相障碍患者的临床资料。采用Kaplan-Meier法绘制生存曲线,利用Cox比例风险模型对患者治疗后1年的生存状况及影响因素进行统计学分析。结果 785例患者接受药物治疗后第2.5、5、7.5、10、12.5个月时的累积生存率分别为0.98、0.96、0.95、0.94和0.65;截至随访终点,82例患者死亡,病死率10.4%;首次治疗后12个月内的病死率为4.3%。多因素Cox回归分析结果显示:躯体疾病共病和联合抗精神病药物的治疗方案与患者生存时间有关。结论对于首次诊断双相障碍的患者,早期联合抗精神病药物治疗可延长患者的生存时间,提高生存率;躯体疾病共病是影响患者生存的危险因素。
[Abstract]:Objective to analyze the survival status and its influencing factors of patients with bipolar disorder diagnosed for the first time and treated with drugs. Methods the clinical data of 785 patients with bipolar disorder were collected and the survival curve was drawn by Kaplan-Meier method. Cox proportional risk model was used to analyze the survival status and influencing factors of patients in one year after treatment. Results the cumulative survival rates of 785 patients after drug therapy were 0.980.960.950.94 and 0.65 respectively at the 1012.5 months after drug therapy. At the end point, 82 patients died, The mortality rate was 10.4 and the mortality within 12 months after the first treatment was 4.3. The results of multivariate Cox regression analysis showed that the treatment regimen of somatic syndromes and combined antipsychotics was related to the survival time of the patients. Conclusion for the first diagnosis, the treatment regimen is related to the survival time of the patients. Patients with bipolar disorder, Early combined therapy with antipsychotics can prolong the survival time and improve the survival rate, and somatic syndromes are the risk factors affecting the survival of patients.
【作者单位】：上海市长宁区精神卫生中心;上海交通大学医学院附属精神卫生中心;
【基金】：上海市长宁区卫生局特色专科建设项目(2012206001) 上海市长宁区卫生局专病建设项目(2011210416) 上海市妇儿委重点项目(201208009) 上海市长宁区政府“领军人才”建设项目~~
【分类号】：R749.4

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