丁苯酞治疗血管性痴呆疗效及安全性的系统性分析

发布时间：2018-04-03 07:28

本文选题：血管性痴呆　切入点：Meta分析　出处：《中国老年学杂志》2017年21期

【摘要】：目的探讨丁苯酞(NBP)软胶囊治疗血管性痴呆(VD)的临床疗效及安全性。方法查阅NBP治疗VD的文献,对其改善神经功能缺损程度、痴呆程度、增强抗氧化能力及不良反应进行分析。结果共纳入文献19篇,1 544例,试验组和对照组各772例。以简易精神状态尽可检查表(MMES)为指标共纳入18篇文献,结果显示试验组MMES评分明显高于对照组(Z=7.98,P0.000 01);以临床痴呆程度量表(CDR)为指标共纳入13篇文献,结果显示试验组CDR评分明显低于对照组(Z=7.89,P0.000 01);以超氧化物歧化酶(SOD)为指标共纳入8篇文献,结果显示试验组SOD活性明显高于对照组(Z=5.01,P0.000 01);以丙二醛(MDA)为指标,共纳入7篇文献,结果显示试验组MDA含量明显降低(Z=3.23,P=0.001);以同型半胱氨酸(Hcy)浓度为指标共纳入2篇文献,结果显示试验组Hcy浓度明显低于对照组(Z=3.23,P=0.001);共有2篇文献分析了疾病疗效,结果显示试验组疗效明显高于对照组(Z=3.18,P=0.001);以不良反应为指标共纳入5篇文献,结果显示两组差异无统计学意义(Z=1.10,P=0.27)。结论 NBP能明显改善神经功能缺损程度、痴呆程度且治疗VD安全有效。
[Abstract]:Objective to investigate the butylphthalide (NBP) soft capsule in the treatment of vascular dementia (VD) the clinical efficacy and safety of NBP for the treatment of VD. Methods of literature, on the improvement of neural function defect degree, the degree of dementia, enhance the antioxidant capacity and adverse reactions were analyzed. Results 19, 1544 cases in the literature were included in the test group and the the control group of 772 cases. The mini mental state examination (MMES) as indicators for a total of 18 articles were included, the results showed that the test group MMES score was significantly higher than that of the control group (Z=7.98, P0.000 01); the clinical dementia rating index (CDR) for a total of 13 articles were included, the results showed that the test group CDR the score was significantly lower than the control group (Z=7.89, P0.000 01); superoxide dismutase (SOD) as the index of a total of 8 articles were included, the results showed that the test group SOD was significantly higher than that of control group (Z=5.01, P0.000 01); the MDA (MDA) as the index, a total of 7 articles were included, the results showed that The test group MDA decreased significantly (Z=3.23, P=0.001); with homocysteine (Hcy) concentration index for a total of 2 articles were included. The results showed that the concentration of Hcy in experimental group was significantly lower than the control group (Z=3.23, P=0.001); a total of 2 literatures analyzed the disease curative effect, results showed that the test group was significantly higher than the control group (Z=3.18, P=0.001); the adverse reactions as indicators of a total of 5 articles were included, the results showed that there was no significant difference between two groups (Z=1.10, P=0.27). Conclusion NBP can significantly improve the neurologic impairment, dementia degree and the treatment of VD is safe and effective.

【作者单位】：天津市咸水沽医院神经科;天津市第三中心医院神经科;
【分类号】：R749.13

【相似文献】