广泛性焦虑障碍患者脑扣带回物质代谢特点探究

发布时间：2018-04-05 12:45

本文选题：广泛性焦虑障碍　切入点：扣带回　出处：《中国临床心理学杂志》2015年01期

【摘要】：目的:检测广泛性焦虑障碍患者(Generalized Anxiety Disorder,GAD)脑扣带回前、后部位相关物质代谢水平,以探究GAD的病理机制。方法:选符合ICD-10诊断标准的GAD患者19名为实验组,20名条件匹配的健康志愿者为对照组。用磁共振质子波普成像技术(1H-Magenetic Resonance Spectroscopy,1H-MRS)对所有入组者行脑扣带回的前、后部位中胆碱化合物(Cho)、肌酸(Cr)、乙酰天冬氨酸(NAA)物质水平测定,并行两组间比较。结果:患者组右扣带回前部皮质中的Cho、Cr,白质中的Cho、Cr、NAA,左扣带回前部皮质中的NAA,右扣带回后部皮质中的Cho、Cho/Cr,左扣带回后部皮质中的Cho、Cho/Cr及白质中的Cho、Cr、NAA水平均高于对照组,差异均有统计学意义(P0.05),且物质代谢水平的增高与HAMA评分呈正相关。结论:GAD患者左右脑扣带回前后部白质、皮质物质代谢水平明显增高,且物质代谢水平越高,焦虑症状越明显。
[Abstract]:Aim: to investigate the metabolic level of related substances in the anterior and posterior cingulate gyrus of generalized Anxiety disorder in patients with generalized anxiety disorder in order to explore the pathological mechanism of GAD.Methods: 19 GAD patients who met ICD-10 diagnostic criteria were selected as control group.1H-Magenetic Resonance Spectroscopy1H-MRSs were used to measure the levels of choline compounds in the anterior and posterior parts of the cingulate gyrus of all the patients. The levels of choline compounds Chochus, creatine cr, and acetyl aspartic acid (NAA) in the anterior and posterior parts of the cingulate gyrus were measured and compared between the two groups.The difference was statistically significant (P 0.05), and there was a positive correlation between the level of substance metabolism and HAMA score.Conclusion the level of substance metabolism in the white matter and cortex in the anterior and posterior cingulate gyrus of the patients with GAD was significantly increased, and the higher the level of substance metabolism was, the more obvious the anxiety symptoms were.
【作者单位】：新疆医科大学第一附属医院心理医学中心;中南大学湘雅二医院精神卫生研究所;新疆医科大学第一附属医院影像中心;
【基金】：新疆医科大学第一附属医院科研奖励基金(2010yry23)
【分类号】：R749.72

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