急性冠脉综合征PCI术后伴抑郁患者左洛复干预的研究

发布时间：2018-04-09 02:15

本文选题：急性冠脉综合征　切入点：PCI　出处：《青岛大学》2014年硕士论文

【摘要】：目的：观察左洛复对急性冠脉综合征(ACS)PCI术后合并抑郁患者抗抑郁治疗的疗效及对其低密度脂蛋白(LDL)、高敏C反应蛋白(hsCRP)的影响。方法：对150例确诊为急性冠脉综合征的患者行PCI术治疗,术后从中筛选出伴有抑郁症患者并通过汉密尔顿(HAMD)抑郁量表对其进行评分。后将合并有抑郁的患者随机分成两组,分别给予心理治疗(对照组)和左洛复治疗(治疗组)。2月后对比两组患者的LDL、hsCRP水平,再次利用HAMD抑郁量表进行评分,根据评分减分率判断左洛复抗抑郁治疗的疗效。结果： (1)2月后治疗组LDL.hsCRP水平(分别为1.70±0.56mmol/L、0.27±0.02ng/ml)明显低于对照组LDL、hsCRP水平(分别为2.13±0.62mmol/L、0.45±0.33ng/ml),差异具有统计学意义(P均0.05)。 (2)经治疗后,两组患者的抑郁症状均得到了改善,与对照组相比,治疗组抗抑郁治疗的效果要明显优于对照组(治愈及显效的例数明显多于对照组),差异具统计学意义(P0.05)。 (3)左洛复引起的药物不良反应与对照组相比无明显增加,两组间差异无统计学意义(P0.1)。结论： (1)对急性冠脉综合征PCI术后合并有抑郁的患者给予左洛复治疗是安全的。 (2)对抑郁的治疗,药物可能比单纯给予心理治疗更有效。 (3)左洛复通过对抑郁的治疗,间接降低冠心病危险因子LDL、hsCRP的水平,对患者预后可能有重要意义。
[Abstract]:Aim: to observe the effect of zolofur on antidepressant treatment of patients with depression after acute coronary syndrome (ACSC) PCI and its effect on low density lipoprotein (LDL) and Gao Min C-reactive protein (Gao Min C reactive protein hsCRP).Methods: 150 patients with acute coronary syndrome were treated with PCI.The patients with depression were randomly divided into two groups. They were treated with psychotherapy (control group) and Zolofu (treatment group). Two months after treatment, the patients in both groups were compared with the level of HAMD hs CRP, and the scores were evaluated by HAMD depression scale.The efficacy of levofloxacin in antidepressant treatment was evaluated according to the score reduction rate.Results:After 2 months, the level of LDL.hsCRP in the treatment group (1.70 卤0.56 mmol / L 0.27 卤0.02 ng / ml, respectively) was significantly lower than that in the control group (2.13 卤0.62 mmol / L 0.45 卤0.33 ng / ml, P < 0.05).2) after treatment, the depressive symptoms of the two groups were improved. Compared with the control group, the effect of antidepressant treatment in the treatment group was obviously better than that in the control group (the number of cured and effective cases was obviously more than that in the control group, the difference was statistically significant (P 0.05).3) there was no significant increase in adverse drug reactions induced by zolofur compared with the control group, and there was no significant difference between the two groups (P 0.1).Conclusion:It is safe to treat acute coronary syndrome patients with depression after PCI.Drugs may be more effective than psychotherapy alone in the treatment of depression.Through the treatment of depression, Zolofu can indirectly reduce the level of LDL- hsCRP, which may play an important role in the prognosis of patients with coronary heart disease.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R541.4;R749.4

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