利培酮致迟发性运动障碍不良反应特点分析

发布时间：2018-04-13 15:33

本文选题：利培酮 + 迟发性运动障碍　；参考：《中国医院药学杂志》2017年19期

【摘要】：目的:分析利培酮导致迟发性运动障碍不良反应的临床用药特点。方法:回顾性分析2004-2015年我院上报的10例利培酮致迟发性运动障碍的药物不良反应,分析患者的性别、年龄、体质量、原患疾病、药物剂型及剂量和发生迟发性运动障碍的潜伏期及临床表现、治疗措施及转归,探讨利培酮导致迟发性运动障碍的特点。结果:10例患者中,男女性各有5例。用药至发生迟发性运动障碍的潜伏期为13~3 505 d,其中用药后1年内发生者6例(占60.0%)。10例患者中,有5例次患者出现颈部异常表现,4例次患者出现肢体扭转,肢体姿势异常或步态异常等症状,6例次患者出现口唇舌部异常动作。10例患者中,出现不良反应后均采取减量、停用利培酮换用其他抗精神病药、密切观察或对症治疗。5例患者好转,4例虽经减量停药或对症处理,仍有后遗症。结论:利培酮所致的迟发性运动障碍临床表现以口唇舌部异常动作,颈部及肢体异常表现为主,其症状多较为严重,可能产生后遗症。另外,小剂量、短期服用利培酮也可能导致迟发性运动障碍,临床用药需谨慎。
[Abstract]:Objective: to analyze the clinical characteristics of risperidone induced delayed dyskinesia.Methods: ten patients with delayed dyskinesia caused by risperidone from 2004 to 2015 were retrospectively analyzed.The latent period and clinical manifestation of the drug dosage and dosage and the occurrence of delayed motor disorder, the treatment measures and the outcome were discussed to explore the characteristics of risperidone induced delayed dyskinesia.Results of 10 cases, 5 cases were male and female.The incubation period from medication to delayed dyskinesia was 13 ~ 3 505 days, of which 6 cases occurred within one year after treatment (60.010 cases), 5 cases had abnormal cervical manifestations and 4 cases had limb torsion.Abnormal posture of limbs or abnormal gait. In 6 patients with abnormal movement of lip and tongue, 10 patients were treated with less treatment after adverse reactions, and other antipsychotics were replaced by risperidone, and other antipsychotic drugs were replaced with risperidone instead of risperidone.Close observation or symptomatic treatment of 5 cases of improvement of the disease 4 cases after the reduction of drug withdrawal or symptomatic treatment, there are still sequelae.Conclusion: the clinical manifestations of delayed dyskinesia caused by risperidone are lip and tongue abnormal movements, neck and limb abnormalities, and its symptoms are more serious and may have sequelae.In addition, low dose, short-term risperidone may also lead to delayed dyskinesia, clinical use of caution.
【作者单位】：首都医科大学附属北京安定医院药事部;首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心;首都医科大学附属北京安定医院精神疾病诊断与治疗北京市重点实验室;首都医科大学附属北京安定医院院部办公室;
【基金】：北京市科技计划项目(编号:Z151100004015180) 北京安定医院人才培养项目(编号:YR-G201508)
【分类号】：R749

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