亚健康与机体慢性氧化应激反应的相关性

发布时间：2018-04-15 18:33

本文选题：亚健康 + 氧化应激　；参考：《广东医学》2014年13期

【摘要】：目的探讨亚健康对机体氧化应激反应的相关性。方法按照亚健康患者的类型,选取躯体性、心理性和社会适应性亚健康患者各20例,以健康者作对照。采用分光光度法及免疫比浊法测各组机体内血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)和丙二醛(MDA)的浓度水平。结果与健康者相比,三种亚健康患者SOD、GSHPx水平降低(P0.01),MDA水平却明显升高(P0.01),躯体性亚健康患者与心理性、社会适应性相比,SOD、GSHPx水平降低更明显(P0.01),MDA水平升高更明显(P0.01)。亚健康患者症状积分与SOD(r=0.802,P0.01)、GSHPx(r=0.640,P0.01)呈正相关,与MAD呈负相关(r=-0.727,P0.01)。结论亚健康患者处于氧化应激状态,其中躯体性亚健康患者相比心理性、社会性亚健康患者更为严重,亚健康与氧化应激之间有明显的相关性。
[Abstract]:Objective to investigate the relationship between sub-health and oxidative stress.Methods according to the type of subhealth patients, 20 patients with physical, psychological and social adaptability were selected as control group.The concentrations of serum superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and malondialdehyde (MDA) were measured by spectrophotometry and immunoturbidimetry.Results compared with the healthy subjects, the level of GSHPx in the three subhealthy patients decreased significantly, but the MDA level of P0.01P was increased significantly. The decrease of GSHPx level in the patients with physical subhealth was more obvious than that in the patients with mental and social adaptability, and the increase of the MDA level in the patients with physical subhealth was more obvious than that in the patients with physical subhealth.There was a positive correlation between symptom score of subhealthy patients and MAD (0.802% P0.01), but a negative correlation with MAD (-0.727% P0.01).Conclusion Subhealth patients are in the state of oxidative stress, and physical subhealth patients are more serious than psychologically subhealth patients, and there is an obvious correlation between subhealth and oxidative stress.
【作者单位】：南方医科大学南方医院健康管理中心;南方医科大学中医药学院;
【分类号】：R749.99

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