艾司西酞普兰联合心理干预治疗青少年抑郁症21例

发布时间：2018-04-20 06:06

本文选题：艾司西酞普兰 + 心理干预　；参考：《医药导报》2014年09期

【摘要】：目的探讨艾司西酞普兰联合心理干预治疗青少年抑郁症的疗效。方法青少年抑郁症患者42例,采用随机数字表法随机分为两组,各21例。治疗组给予艾司西酞普兰10 mg·d-1口服,qd,联合心理干预治疗;对照组给予艾司西酞普兰10 mg·d-1口服,qd,并对两组进行为期1年的随访观察。在治疗前及治疗第6,12周采用汉密尔顿抑郁量表(HAMD)、焦虑自评量表(SAS)以及临床疗效总评量表病情严重程度(CGI-SI)对两组进行评估,应用药物不良反应量表(TESS)对两组不良反应发生情况进行统计。结果治疗组在治疗6,12周时HAMD、SAS、CGI-SI评分较对照组差异有统计学意义(均P0.05),两组之间不良反应发生情况无统计学意义(P0.05)。经过1年随访,治疗组和对照组复发率分别为4.76%和33.33%(P0.05)。结论艾司西酞普兰联合心理干预治疗对青少年抑郁症起效快、疗效好,复发率低,是治疗青少年抑郁的理想方法之一。
[Abstract]:Objective to investigate the efficacy of Escitalopram combined with psychological intervention in the treatment of adolescent depression. Methods 42 patients with adolescent depression were randomly divided into two groups, 21 cases each. The treatment group was given estalopram 10 mg 路d ~ (-1) orally, combined with psychological intervention, while the control group was given estalopram 10 mg 路d ~ (-1) orally, and the two groups were followed up for one year. The two groups were evaluated with Hamilton Depression scale (Hamd), Self-Rating anxiety scale (SAS) and Clinical efficacy scale (CGI-SII) before and at the 6th week of treatment. Adverse drug reaction scale (TESS) was used to analyze the occurrence of adverse drug reactions in the two groups. Results there was a significant difference in CGI-SI scores between the two groups at the 12th week after treatment (all P 0.05), and there was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). After 1 year follow-up, the recurrence rates of treatment group and control group were 4.76% and 33.33% respectively. Conclusion Escitalopram combined with psychological intervention is one of the ideal methods for the treatment of adolescent depression, which has the advantages of quick onset, good curative effect and low recurrence rate.
【作者单位】：河南省开封市第五人民医院二病区;
【分类号】：R749.41

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