康复综合治疗对阿尔茨海默病患者脑电特征影响的研究

发布时间：2018-04-21 14:58

本文选题：阿尔茨海默病 + 脑电描记术　；参考：《中华老年心脑血管病杂志》2014年05期

【摘要】：目的探讨康复综合治疗对阿尔茨海默病(AD)患者脑电特征的影响。方法选择AD患者30例,按照随机数字表法分为治疗组15例和对照组15例。2组患者进行相同药物治疗,治疗组患者在药物治疗基础上增加康复综合治疗。于治疗前、治疗3个月后分别进行简易智能状态检查量表(MMSE)、Barthel指数(BI)及脑电特征分析,比较2组测评结果及相关性。结果治疗组治疗后MMSE、BI评分较治疗前及对照组治疗后明显提高,差异有统计学意义(P0.05);治疗组治疗后脑电信号高频带相对功率比值较治疗前和对照组治疗后明显增加[β1:(1.254±0.331)vs(0.883±0.204)、(0.853±0.287);β2:(1.033±0.256)vs(0.679±0.413)、(0.628±0.117),P0.05]。脑电高频带β1、β2相对功率比值与MMSE评分呈正相关(r=0.67,r=0.57,P0.01),与BI评分相关性较低(r=0.34,r=0.30,P0.05)。治疗组治疗后δ、θ频带比值较治疗前明显降低,α、β频带比值较治疗前明显增高(P0.05),对照组治疗前后各频带比值无明显变化。结论康复综合治疗对于改善AD患者认知及日常生活活动能力具有积极作用,通过脑电特征分析可客观评价康复治疗效果。
[Abstract]:Objective to investigate the effect of comprehensive rehabilitation therapy on EEG characteristics in patients with Alzheimer's disease (AD). Methods Thirty patients with AD were randomly divided into treatment group (n = 15) and control group (n = 15). The MMSE Barthel index (BI) and EEG characteristics were analyzed before and 3 months after treatment. The results and correlation between the two groups were compared. Results after treatment, the MMSE BI score in the treatment group was significantly higher than that before treatment and after treatment in the control group, the difference was statistically significant (P 0.05), and the relative power ratio of high-frequency band of EEG in the treatment group was significantly higher than that before treatment and after treatment in the control group [尾 _ 1: 1. 254 卤0.204 0.331)vs(0.883 卤0.853 卤0.28775; 尾 _ 2: 1.033 卤0.41313 ~ (5) 卤0.628 卤0.117 (P0.05)]. The relative power ratio of 尾 _ 1 and 尾 _ 2 in high frequency band of EEG was positively correlated with MMSE score (0.67 ~ 0.57) P 0.01a, and had a lower correlation with BI score (0.34 ~ 0.30 ~ (0.30)) P _ (0.05). The ratio of 未 and 胃 bands in the treatment group was significantly lower than that before treatment, and the ratio of 伪 and 尾 band was significantly higher than that before treatment (P 0.05), while in the control group, there was no significant change in the ratio of each band before and after treatment. Conclusion Comprehensive rehabilitation therapy has a positive effect on improving the cognitive and daily living ability of AD patients, and the effect of rehabilitation treatment can be evaluated objectively by analyzing the characteristics of EEG.
【作者单位】：天津市环湖医院康复科;
【分类号】：R749.16

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