蔗糖奖赏增强大鼠对可卡因的觅药动机

发布时间：2018-04-21 16:37

本文选题：蔗糖 + 可卡因　；参考：《生理学报》2016年03期

【摘要】：高糖、高脂食物的摄取会产生奖赏效应。研究表明,高糖食物,如蔗糖或糖水的摄食经历,会影响动物对成瘾性药物的应答,但是动物对高糖食物的摄取是否影响其对成瘾性药物的觅药动机并不清楚。本研究通过自给食踏板训练使大鼠进行蔗糖摄食,并观察蔗糖自给食经历是否影响大鼠对可卡因的觅药动机。在可卡因自给药实验中,与食物对照组相比,经历蔗糖自给食的大鼠表现出较高的踏板数和摄药量、递增比率的踏板破发点以及上移的剂量反应踏板曲线,提示对可卡因觅药动机的升高;在可卡因诱导的活动敏感性实验中,经历蔗糖自给食的大鼠表现出较高的活动敏感性;在可卡因条件性位置偏爱实验和旷场实验中,经历蔗糖自给食的大鼠对可卡因配对侧的偏爱和自主活动性与食物对照组相比无显著差异;在高架十字迷宫以及条件性恐惧记忆实验中,经历蔗糖自给食的大鼠的焦虑水平以及对声音线索引起的僵直反应与食物对照组相比没有显著变化。这些结果提示,蔗糖奖赏能够增强大鼠对可卡因的觅药动机。
[Abstract]:High sugar, high fat food intake will have a reward effect. Studies have shown that high-sugar foods, such as sucrose or sucrose, can affect the response of animals to addictive drugs, but it is not clear whether the intake of high-sugar foods affects their motivation to look for addictive drugs. In this study, the rats were fed sucrose by self-feeding pedal training, and the effects of sucrose self-feeding experience on the motivation of cocaine seeking in rats were observed. In the cocaine self-administered experiment, the rats experienced sucrose self-feeding showed higher pedal number and intake, increased pedal break point and up-shift dose-response pedal curve than those in the food control group. The results indicated that the motivation of cocaine seeking was increased; in the activity sensitivity test induced by cocaine, the rats experienced sucrose self-feeding showed higher activity sensitivity; in cocaine conditioned place preference experiment and open field experiment, There was no significant difference in the preference and autonomous activity of cocaine pairs between rats with sucrose sucrose sucrose self-feeding compared with the food control group; in the elevated cross maze and conditioned fear memory experiments, there was no significant difference between the two groups. There was no significant change in anxiety level and the stiffness response to sound cues in the sucrose sucrose self-feeding rats compared with the food control group. These results suggest that sucrose rewards increase the rats' motivation to seek cocaine.
【作者单位】：复旦大学基础医学院医学神经生物学国家重点实验室药理研究中心;
【基金】：supported by the National Natural Science Foundation of China(No.91232307)
【分类号】：R749.6

【相似文献】