阿尔茨海默病和轻度认知障碍患者视网膜纤维层和黄斑异常的研究

发布时间：2018-04-25 05:22

本文选题：阿尔茨海默病 + 轻度认知障碍　；参考：《中风与神经疾病杂志》2014年04期

【摘要】：目的本研究通过光学相干断层显像仪(OCT)观察阿尔茨海默病(AD)患者及轻度认知障碍(MCI)患者视网膜纤维层(RNFL)厚度和黄斑厚度及容积与正常对照组是否存在异常。方法阿尔茨海默病患者25人,轻度认知障碍患者26人,正常对照组20人。通过OCT对入组者RNFL及黄斑进行观察,以P0.05作为差异有统计学意义。结果 AD组的RNFL厚度较对照组减小,除鼻侧象限、12:00、2:00、3:00、4:00以外均达到统计学意义。AD组RNFL厚度较MCI组变薄,平均厚度、下象限、5:00、6:00、10:00和11:00的差异有统计学意义(P0.05)。与对照组相比时,MCI患者的RNFL厚度在上象限、颞侧象限及8:00、10:00、11:00明显变薄且有统计学意义。AD组黄斑容积较对照组明显减小,且P0.05。结论 AD和MCI患者出现视神经视网膜退行性变,表现为视网膜纤维层厚度平均值及不同位点选择性的变薄和黄斑容积的改变。
[Abstract]:Objective To observe whether the retinal fiber layer (RNFL) thickness and macular thickness and volume of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) were abnormal in the control group by optical coherence tomography (OCT). Methods 25 patients with Alzheimer's disease, 26 patients with mild cognitive impairment, and 20 normal controls. RNFL and macula were observed by OCT, and the difference of P0.05 was statistically significant. Results the thickness of RNFL in group AD was smaller than that of the control group. Except for the nasal quadrant, the thickness of RNFL in.AD group was thinner than that of the MCI group. The mean thickness, lower quadrant, 5:00,6:00,10:00 and 11:00 were statistically significant. P0.05. Compared with the control group, the RNFL thickness of the MCI patients was in the upper quadrant, the temporal quadrant and the 8:00,10:00,11:00 were significantly thinner and significantly decreased in.AD group than in the control group, and P0.05. concluded that the retina degeneration of the optic nerve was found in AD and MCI patients, showing the average value of the retinal thickness and the different loci. Selective thinning and changes in macular volume.

【作者单位】：大连市友谊医院神经内科;
【分类号】：R749.1

【参考文献】