GAD1基因SNPrs11542313多态性与精神分裂症及其认知功能的关联研究

发布时间：2018-04-26 12:29

本文选题：精神分裂症 + 谷氨酸脱羧酶1基因　；参考：《昆明医科大学》2012年硕士论文

【摘要】：目的探讨昆明地区汉族人群GAD1基因SNPrs11542313多态性与精神分裂症及认知功能的关系。方法采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)的方法检测74例精神分裂症患者、78例一级亲属和59名健康对照的GAD1基因SNPrs11542313多态性；采用韦氏智力量表(WAIS)、韦氏记忆量表(WMS)和威斯康辛卡片分类测验(WCST)评估三组人群的智力功能、记忆功能和执行功能,并用PANSS量表评定患者的临床症状。结果三组GAD1基因SNPrs11542313多态性的基因型和等位基因频率差异无统计学意义(P0.05)。精神分裂症患者在算术、数字符号、木块图、长时记忆方面比健康对照组和／或一级亲属差,三者之间的比较有显著性差异(p0.05)；精神分裂症患者组的三个基因型之间的认知功能比较无显著性差异(p0.05)。结论精神分裂症患者存在广泛的认知功能损害,精神分裂症一级亲属在认知功能部分领域也存在认知功能损害。GAD1基因SNPrs11542313的基因多态性与精神分裂症和患者的认知功能可能无关。
[Abstract]:Objective to investigate the relationship between GAD1 gene SNPrs11542313 polymorphism and schizophrenia and cognitive function in Kunming Han population. Methods Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to detect the GAD1 gene SNPrs11542313 polymorphism in 78 first-degree relatives of 74 schizophrenic patients and 59 healthy controls. Wechsler Intelligence scale (WIS), Wechsler memory scale (WMS) and Wisconsin Card sorting Test (Wisconsin) were used to evaluate the intelligence, memory and executive function of the three groups. The clinical symptoms of the patients were evaluated with PANSS. Results there was no significant difference in genotype and allele frequency of SNPrs11542313 polymorphism of GAD1 gene among the three groups (P 0.05). Schizophrenics were worse at arithmetic, digital symbols, block charts, long-term memory than healthy controls and / or first-degree relatives. There was no significant difference in cognitive function among the three genotypes in schizophrenic patients. Conclusion there are extensive cognitive impairment in schizophrenic patients, and the genetic polymorphisms of GAD1 gene SNPrs11542313 in some areas of cognitive function may not be related to the cognitive function of schizophrenia and patients.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.3

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