文拉法辛与艾司西酞普兰治疗躯体形式障碍的随机对照研究

发布时间：2018-04-30 08:18

本文选题：文拉法辛 + 艾司西酞普兰　；参考：《华中科技大学》2013年硕士论文

【摘要】：目的：比较文拉法辛与艾司西酞普兰治疗躯体形式障碍的临床疗效及安全性。方法：根据治疗方法的不同，将符合美国精神疾病诊断与统计手册第四版（DSM-IV）躯体形式障碍诊断标准的100例门诊患者随机分为文拉法辛组（n=50）和艾司西酞普兰组（n=50），文拉法辛组服用文拉法辛，第1周口服75mg/d，以后加量为150mg/d；艾司西酞普兰组服用艾司西酞普兰，第1周口服10mg/d，以后加量为15mg/d，观察8周。于治疗后的第2、4、8周末进行治疗效果及副反应的评定，采用汉密尔顿抑郁量表（HAMD），汉密尔顿焦虑量表（HAMA）和不良反应症状量表（TESS）来评定。结果：文拉法辛与艾司西酞普兰治疗躯体形式障碍均有疗效，两组在治疗前后HAMD及HAMA评分显著下降，差异有统计学意义（P0.01）；在第2周末，艾司西酞普兰组的HAMD减分率轻微高于文拉法辛组，差异有统计学意义（P0.05）；但是在第4周及第8周末文拉法辛组的HAMD减分率明显高于艾司西酞普兰组，差异有统计学意义（P 0.01）；另外，文拉法辛组的不良反应发生率为35.42%，艾司西酞普兰组的不良反应发生率为12%，差异有统计学意义（P0.05）。结论：文拉法辛治疗躯体形式障碍的疗效优于艾司西酞普兰，，但是艾司西酞普兰起效较文拉法辛快，而且药物的不良反应轻，对患者来说有很好的依从性。
[Abstract]:Objective : To compare the clinical efficacy and safety of Wenlamethod and escitalopram in the treatment of somatoform disorders .

Methods : According to the different methods of treatment , 100 outpatients who met the criteria for the diagnosis and diagnosis of somatic disorders of mental disorders in the United States were randomly divided into Wenlamethod Xin group ( n = 50 ) and escitalopram group ( n = 50 ) .
escitalopram was administered orally for 10 mg / day in the first week and 15 mg / d for 8 weeks . The treatment effect and side effects were assessed at the 2nd , 4th and 8th weekend after treatment .

Results : The curative effect of Wenlamethod and escitalopram in the treatment of somatoform disorder were significant , and the scores of HAMA were significantly decreased in both groups before and after treatment ( P0.01 ) .
At the end of the second week , there was a slight difference between the scores of the escitalopram group ( P0.05 ) .
But in the 4th week and the 8th week , the rate of reduction was significantly higher than that of escitalopram group ( P 0.01 ) .
In addition , the incidence of adverse reactions was 35.42 % , and the incidence of adverse reactions was 12 % in escitalopram group ( P0.05 ) .

Conclusion : The therapeutic effect of Venacine in the treatment of somatoform disorder is better than that of escitalopram , but the efficacy of escitalopram is faster than that of escitalopram , and the adverse reaction of the drug is mild , which is very good for patients .

【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.2

【参考文献】