原发性高血压患者合并抑郁障碍与血浆同型半胱氨酸水平的相关性研究

发布时间：2018-04-30 09:26

本文选题：原发性高血压 + 抑郁障碍　；参考：《新疆医科大学》2013年硕士论文

【摘要】：目的：探究原发性高血压（EH）患者合并抑郁障碍与血浆同型半胱氨酸水平（Hcy）之间的相关性。方法：收集2011年8月-2012年6月在我院干部病房内科住院治疗的原发性高血压患者163例，高血压诊断符合2005年高血压诊断标准。所有入选患者均通过Zung抑郁自评量表（SDS）和综合医院焦虑抑郁量表抑郁分表筛查患者抑郁障碍，用循环酶法测定血浆同型半胱氨酸（Hcy）水平。结果：本研究中共有69例（42.3%）患者合并抑郁障碍；有31例患者发生高同型半胱氨酸血症（HHcy）；将163例患者按是否合并抑郁障碍分为抑郁组和非抑郁组，两组患者在年龄、体质指数、高血压病程、高血压分级、冠心病合并率间差异均无统计学意义（P＞0.05）；在性别、Hcy水平及高Hcy血症发生人数间差异有统计学意义（P＜0.05），其中女性高血压患者抑郁障碍的发生率高于男性（53.8%，36.9%，x~2=4.417，P=0.031），合并抑郁障碍组的血浆Hcy水平高于未合并抑郁组者［(12.89±9.17)μmol/L和（10.44±8.02）μmol/L，t=1.774，P=0.039］，HHcy发生率也明显高于未合并抑郁组（26.1%，13.8%，x~2=3.882，P=0.039）。将163例患者按血压水平分为3组，不同血压分级间患者血浆Hcy水平差异无统计学意义（P＞0.05），不同血压分级间患者SDS评分差异有统计学意义(P＜0.05)。结论：原发性高血压患者有较高的抑郁障碍发生率，且存在性别差异，，女性高于男性；合并抑郁障碍的高血压患者血浆中Hcy水平及HHcy发生率均增加。
[Abstract]:Objective: To investigate the correlation between depressive disorder and plasma homocysteine level (Hcy) in patients with essential hypertension (EH). Methods: 163 patients with essential hypertension hospitalized in the medical department of our hospital in June August 2011 were collected. The diagnosis of hypertension was in accordance with the diagnostic criteria of hypertension in 2005. All the patients were selected. The Zung depression self rating scale (SDS) and the general hospital anxiety and depression scale depression scale were used to screen the depressive disorder and the plasma homocysteine (Hcy) levels were measured by circulating enzyme. Results: 69 cases (42.3%) patients with depressive disorder were combined with depressive disorder; 31 patients with hyperhomocysteinemia (HHcy); and 163 patients. There were no significant differences between the two groups in age, body mass index, hypertension course, hypertension classification, and the rate of coronary heart disease (P > 0.05), and there were significant differences in the gender, Hcy level and high Hcy number (P < 0.05), among which women were hypertensive patients. The incidence of depressive disorder was higher than that of men (53.8%, 36.9%, x~2=4.417, P=0.031). The level of plasma Hcy in the group with depressive disorder was higher than that in the non depression group [(12.89 + 9.17) mu mol/L and (10.44 + 8.02) mu mol/L, t=1.774, P=0.039], and the incidence of HHcy was significantly higher than that in the uncombined depression group (26.1%, 13.8%, x~2=3.882, P=0.039). The blood pressure level was divided into 3 groups. There was no significant difference in plasma Hcy level in patients with different blood pressure grades (P > 0.05). The difference of SDS score between different blood pressure classification patients was statistically significant (P < 0.05). Conclusion: the incidence of depressive disorder in patients with primary hypertension was higher, and there was gender difference, women were higher than men, and depression was associated with depressive disorder. The level of plasma Hcy and HHcy increased in patients with hypertension.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R544.11;R749.4

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