缓解期精神分裂症患者及其一级非患病亲属神经系统软体征比较研究

发布时间：2018-05-02 08:56

本文选题：精神分裂症 + 缓解期　；参考：《中国神经精神疾病杂志》2017年02期

【摘要】：目的探讨缓解期的精神分裂症患者及其非患病一级亲属神经系统软体征(neurological soft signs,NSS)的差异。方法使用中文版剑桥神经科检查(the Cambridge neurological inventory,CNI)软体征测试分量表对86例缓解期精神分裂症患者(患者组)、86名患者的非患病一级亲属(亲属组)和86名健康对照(对照组)进行NSS的评估。结果与亲属组比较,患者组NSS总分、运动协调因子及感觉整合因子得分更高(P0.01)。患者组与对照组比较,患者组的NSS总分、运动协调因子得分和感觉整合因子的得分更高(P0.01)。亲属组与对照组比较,亲属组的NSS总分和运动协调因子得分更高(P0.01)。结论缓解期的精神分裂症患者及其非患病一级亲属较正常对照有更多神经系统软体征,而患者的神经系统软体征多于其非患病一级亲属。神经系统软体征中的运动协调因子可能为精神分裂症潜在的内表型。
[Abstract]:Objective to investigate the difference of neurological soft signs (NSSs) in patients with schizophrenia and their non-diseased first-degree relatives. Methods 86 patients with remission schizophrenia (86 patients with schizophrenia) and 86 healthy controls (control group) were assessed with the Chinese version of the Cambridge Neurological examination (Cambridge Neurological examination) subscale for the sign of the Cambridge neurological inventory (CNI) in non-diseased first-degree relatives (kinship group) and 86 healthy controls (control group, n = 86). The NSS was evaluated. Results compared with the relative group, the total score of NSS, motor coordination factor and sensory integration factor in the patients group were higher than those in the relative group (P 0.01). Compared with the control group, the total score of NSS, motor coordination factor and sensory integration factor in the patient group were higher than those in the control group (P 0.01). Compared with the control group, the total NSS score and the motor coordination factor score in the relatives group were higher than those in the control group (P 0.01). Conclusion there are more nervous system soft signs in patients with schizophrenia and their non-diseased first-degree relatives than in the normal controls, and the neurological soft signs of the patients are more than those of their non-diseased first degree relatives. Motor coordination factors in soft signs of nervous system may be potential endophenotypes of schizophrenia.
【作者单位】：华中科技大学同济医学院附属武汉精神卫生中心精神科;华中科技大学同济医学院附属武汉精神卫生中心心理测量科;
【基金】：2013年度武汉市卫计委公共卫生科研项目(编号:WG13B07)
【分类号】：R749.3

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