抽动障碍患儿血清25羟基维生素D水平的检测

发布时间：2018-05-03 20:48

本文选题：抽动障碍 + 维生素D　；参考：《中国当代儿科杂志》2017年11期

【摘要】：目的了解抽动障碍(TD)患儿维生素D的营养状况,探讨维生素D水平与TD的关系。方法选取2016年11月至2017年5月诊断为TD的132例患儿为TD组,其中抽动秽语综合征患儿8例,慢性运动或发声抽动障碍患儿32例,暂时性抽动障碍患儿92例;另选取同期行体检的健康儿童144例为健康对照组。采集两组儿童外周静脉血3 m L,留取血清,采用高效液相色谱-串联质谱法检测两组儿童血清25羟基维生素D[25(OH)D]水平,根据血清25(OH)D水平,30 ng/m L为正常、10~30 ng/m L为不足、10 ng/m L为缺乏。结果 TD患儿血清25(OH)D水平明显低于健康对照组(P0.01);TD患儿血清25(OH)D不足或缺乏率明显高于健康对照组(P0.01);暂时性抽动障碍患儿血清25(OH)D水平高于抽动秽语综合征患儿(P0.05)。结论维生素D缺乏或不足可能是导致TD发病的因素之一;且维生素D水平高低可能与TD分型存在关联。
[Abstract]:Objective to investigate the nutritional status of vitamin D and the relationship between vitamin D level and TD in children with TDs. Methods 132 children with TD from November 2016 to May 2017 were selected as TD group, including 8 children with Tourette syndrome, 32 children with chronic motor or phonation tic disorder and 92 children with temporary tic disorder. Another 144 healthy children who underwent physical examination at the same time were selected as the healthy control group. Serum samples were collected from the peripheral venous blood of the two groups, and the serum levels of 25 hydroxyvitamin D [25(OH)D] were detected by high performance liquid chromatography-tandem mass spectrometry (HPLC / MS). According to the serum 25(OH)D level of 30 ng/m / L, 10 030 ng/m / L and 10 ng/m / L, the deficiency was 10 / 10 ng/m / L, respectively. Results the level of serum 25(OH)D in children with TD was significantly lower than that in healthy controls (P 0.01), and the level of serum 25(OH)D in children with temporary tic disorder was higher than that in children with Tourette syndrome (P 0.05). Conclusion Vitamin D deficiency or deficiency may be one of the factors leading to the onset of TD, and the level of vitamin D may be associated with TD typing.
【作者单位】：吉林大学第一医院发育行为儿科;
【分类号】：R749.94

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