COMT基因Val158Met多态性与精神分裂症患者暴力行为关联的meta分析

发布时间：2018-05-07 19:31

本文选题：儿茶酚胺氧位甲基转移酶基因 + 多态性　；参考：《中国心理卫生杂志》2014年07期

【摘要】：目的:探讨儿茶酚胺氧位甲基转移酶(COMT)基因Val158Met多态性与精神分裂症患者暴力行为的具体关联。方法:计算机检索PubMed、Embase、Web of Science、Google学术、中国生物医学文献数据库、万方、维普、中国知网等中英文数据库,收集有关COMT基因多态性与精神分裂症患者暴力行为相关联的病例对照研究,纳入文献的质量评价参照Newcastle-Ottawa Scale(NOS)评分量表进行,评分≥7分为高质量文献。根据患者是否有攻击行为,将患者分为暴力组和非暴力组。数据分析采用STATA12.0软件进行,计算比值比(OR)及其95%可信区间(95%CI)分析COMT基因Val158Met多态性与精神分裂症患者暴力行为5种不同遗传性模型下的关联性。结果:共纳入17项研究,包括3276例精神分裂症患者,暴力组为1523例,非暴力组为1753例,其中15项研究质量评分≥7,仅2项研究质量评分7。Meta分析结果表明,COMT基因Val158Met多态性与精神分裂症患者暴力倾向有关联(Met vs.Val:OR=1.18,95%CI:1.05~1.32;Val/Met+Met/Met vs.Val/Val:OR=1.23,95%CI:1.06~1.43)。结论:COMT基因Val158Met多态性可能与精神分裂症患者的暴力行为存在关联。
[Abstract]:Objective: To investigate the specific association of Val158Met polymorphism of catecholamine methyltransferase (COMT) gene and the violent behavior of schizophrenic patients. Methods: a computer retrieval of PubMed, Embase, Web of Science, Google academic, Chinese biomedical literature database, Wanfang, VIP, Chinese knowledge network, etc. A case-control study associated with violence in schizophrenic patients was conducted in reference to the quality evaluation of the literature referring to the Newcastle-Ottawa Scale (NOS) scale. The score was more than 7 in the high quality literature. According to the aggressive behavior of the patients, the patients were divided into violent and non violent groups. The data analysis was carried out by the STATA12.0 software, The odds ratio Ratio (OR) and its 95% confidence interval (95%CI) were used to analyze the correlation between the Val158Met polymorphism of COMT gene and the 5 different genetic models of schizophrenic patients. Results: there were 17 studies, including 3276 schizophrenic patients, 1523 violence groups, and 1753 non violent groups, 15 of which were more than 7 of the quality score. Only 2 studies of quality score 7.Meta analysis showed that the Val158Met polymorphism of the COMT gene was associated with the violent tendency of schizophrenic patients (Met vs.Val:OR=1.18,95%CI:1.05~1.32; Val/Met+Met/Met vs.Val/Val:OR=1.23,95%CI:1.06~1.43). Conclusion: the Val158Met polymorphism of COMT gene may be associated with the violent behavior of schizophrenic patients. Relation.

【作者单位】：沈阳市精神卫生中心精神科;中国医科大学附属第一医院心理科;中国医科大学附属第二医院心理科;中国医科大学附属第四医院心理科;
【分类号】：R749.3

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