阿尔茨海默病患者经颅磁刺激治疗的meta分析

发布时间：2018-05-08 08:36

  本文选题：阿尔兹海默病 + 经颅磁刺激　； 参考：《科技导报》2017年09期

【摘要】：目前经颅磁刺激(repetitive transcranial magnetic stimulation)对阿尔茨海默病(Alzheimer's disease)的疗效具有争议性。检索2015年12月以前Embase、medline、Cochrane Library、Ovid、Pubmed、Web of science、中国知网、万方医学网数据库,按照既定的纳入标准和排除标准查找rTMS治疗AD的临床随机对照试验。使用Rev Man5.3软件,应用标准误均数差(standardised mean difference),95%可信区间(confidence interval)分析。共纳入5个随机对照试验进行meta分析,共223例患者,其中rTMS组137例,对照组86例,MMSE结果显示rTMS组疗效线显著优于对照组,(SMD=1.05,95%CI:0.21、1.88,p=0.01,n=141),亚组分析显示高频组(1 Hz)(p=0.02)疗效优于低频组(≤1 Hz)(p=0.27);ADAS-cog结果显示rTMS治疗显著优于对照组,(SMD=-0.71,95%CI:-1.04、-0.39,p0.0001,n=168),高频组(1 Hz)(p0.001)比低频组(≤1 Hz)(p=0.05)疗效更佳。分析结果显示rTMS对AD认知功能有显著改善效果,且高频治疗效果优于低频治疗,然而仅纳入5个研究,后期需要增大随机对照试验样本量验证上述结论。
[Abstract]:The efficacy of transcranial magnetic stimulation (TMS) in Alzheimer's disease is controversial. To search for the database of Embase medline and Cochrane Library Ovidna Pubmedan Web of Science, China Zhiwang, Wanfang Medical Network before December 2015, and to search for clinical randomized controlled trials of AD treated with rTMS according to established inclusion criteria and exclusion criteria. Rev Man5.3 software is used to analyze 95% confidence intervalency of 95% confidence interval. Meta analysis was carried out in 5 randomized controlled trials, including 137 patients in rTMS group. The results of MMSE of 86 cases in the control group showed that the curative effect line of rTMS group was significantly better than that of control group SMD-1.0595 CI0.211.88p0.01p0.01p0. 01%. The result of subgroup analysis showed that the curative effect of rTMS group was better than that of low-frequency group (鈮，

本文编号：1860708