双相障碍I型患者缓解期昼夜静息-活动节律与睡眠模式的体动记录研究

发布时间：2018-05-11 05:02

本文选题：双相障碍I型 + 缓解期　；参考：《中国心理卫生杂志》2016年03期

【摘要】：目的:探讨双相障碍I型患者缓解期昼夜静息-活动节律和睡眠模式的特点。方法:纳入符合精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的20例双相障碍I型缓解期患者和20例年龄、性别匹配的正常对照者,分别连续佩戴7天的Actigraph体动记录仪,比较两组间的主观睡眠情况(使用匹兹堡睡眠质量指数量表)和客观睡眠参数、活动量的平均值以及昼夜静息-活动节律参数指标(Actigraph监测记录)。结果:双相障碍I型患者缓解期组昼夜静息-活动节律变异性高于正常对照组[(0.8±0.1)vs.(0.7±0.1),P0.01],而两组的日间稳定性差异无统计学意义(P0.05);经体质量加权后,双相障碍I型患者缓解期组的活动量明显低于正常对照组[(13.9±5.0)k J/kg vs.(17.8±3.2)k J/kg,P0.01];双相障碍I型患者缓解期组在静坐级活动所耗时间比正常对照组长[(18.2±2.0)h vs.(16.8±1.2)h,P0.05],在轻度至活跃级活动所耗时间比正常对照组短[0.8(0.1,7.8)h vs.2.0(1.0,7.6)h,P0.001],而在生活方式级活动时间差异无统计学意义;双相障碍I型患者缓解期组与正常对照组的客观睡眠参数差异无统计学意义。结论:双相障碍I型患者即使在缓解期仍具有明显的昼夜静息-活动节律的紊乱,特别是昼夜节律性改变。
[Abstract]:Objective: to investigate the characteristics of sleep pattern and rest-activity rhythm in patients with bipolar disorder type I during remission. Methods: twenty patients with bipolar disorder type I remission and 20 normal controls with age and sex matched with the diagnostic criteria of DSM-IV4 of the Diagnostic and Statistical Manual for Mental Disorder were included. They were respectively wearing Actigraph volume recorder for 7 days. Subjective sleep (using Pittsburgh Sleep quality Index), objective sleep parameters, average activity and circadian resting rhythm parameters were compared between the two groups. Results: the circadian resting-activity rhythm variability in patients with bipolar disorder I in remission stage was higher than that in normal control group [0. 8 卤0.1)vs.(0.7 卤0. 1], but there was no significant difference in daytime stability between the two groups (P 0. 05), and weighted by body mass, there was no significant difference in day to day stability between the two groups. The activity of patients with bipolar disorder I in remission stage was significantly lower than that in normal control group [13.9 卤5.0 J/kg vs.(17.8 卤3.2kJ / kg P0.01], and the duration of sedentary activity in patients with bipolar disorder I in remission stage was longer than that in normal control group [18.2 卤2.0 hours vs.(16.8 卤1.2 hP0.05], and that in mild to active activity group was significantly lower than that in normal control group (P 0.05). The time consumption was shorter than that in the normal control group [0.8 0. 1 + 7. 8 h vs. 2. 0. 0. 0. 0. 0. 0 0. 0 0. 6 hp. 001], but there was no significant difference in the activity time in lifestyle level. There was no significant difference in objective sleep parameters between remission group and normal control group. Conclusion: bipolar disorder type I patients still have significant disturbance of circadian resting-activity rhythm, especially the circadian rhythm.
【作者单位】：暨南大学附属第一医院精神医学科;香港中文大学精神科学系;
【分类号】：R749.4

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