海洛因诱导条件性位置偏爱大鼠颞叶联络皮层遥测脑电的分析

发布时间：2018-05-16 12:33

本文选题：海洛因 + 海洛因诱导　；参考：《中南大学学报(医学版)》2014年09期

【摘要】：目的:分析海洛因诱导条件性位置偏爱(conditioned place preference,CPP)大鼠颞叶联络皮层(temporal association cortex,TeA)脑电变化与觅药行为产生的关系。方法:运用大鼠脑立体定位技术对TeA区进行电极埋藏,通过CPP视频系统结合脑电无线遥测技术,分别实时记录手术对照组(n=10)、海洛因诱导CPP组(n=20)大鼠TeA区黑、白箱停留状态、黑-白箱穿梭和白-黑箱穿梭时脑电变化,分析其各脑电波百分比差异。结果:与手术对照组比较,海洛因诱导CPP组大鼠在黑、白箱停留状态,左、右侧TeA区θ波百分比显著增加(P0.05,P0.01);大鼠黑-白箱、白-黑箱穿梭时,海洛因诱导CPP组左、右侧TeA区δ波百分比显著减少(P0.01),β波百分比显著增加(P0.01),尤其表现为β2波显著增加(P0.05,P0.01)。与海洛因诱导CPP组大鼠黑箱停留状态比较,黑-白箱穿梭时右侧TeA区θ波百分比显著减少,β波百分比显著增加,尤其以β2波增加明显(P0.01);与海洛因诱导CPP组大鼠白箱停留状态比较,白-黑箱穿梭时右侧TeA区θ波百分比显著减少(P0.01),但β波差异无统计学意义(P0.05)。结论:海洛因诱导CPP大鼠右侧TeA区快波(β,β2)频率增加,伴有θ波频率的相应减少,可能与海洛因诱导CPP大鼠觅药行为产生有关。
[Abstract]:Aim: to investigate the relationship between the changes of temporal association cortexa Tea in the temporal lobe junction cortex of heroin induced conditioned place preference (CPP) rats and the drug seeking behavior. Methods: the electrode of TeA region was implanted by stereotactic localization technique of rat brain. By means of CPP video system and EEG wireless telemetering technique, the status of black and white box in TeA area of rats induced by heroin was recorded in real time, respectively, in the control group (n = 10) and heroin induced CPP group (n = 20). The EEG changes of black-white box shuttle and white-black box shuttle were analyzed. Results: compared with the operation control group, the percentage of 胃 wave in the left and right TeA regions of the CPP rats induced by heroin significantly increased in the black and white box, the percentage of 胃 waves in the right and left TeA regions increased significantly, while in the black and white boxes, the rats in the heroin induced CPP group were left, while the rats in the black and white box, white and black boxes were shuttled by heroin. In the right TeA region, the percentage of 未 wave decreased significantly (P 0.01) and the percentage of 尾 wave increased significantly (P 0.01), especially in 尾 2 wave. Compared with heroin induced CPP rats, the percentage of 胃 wave and 尾 wave in the right side of TeA decreased significantly, and the percentage of 尾 wave increased significantly during the shuttle between black and white boxes. Compared with CPP rats induced by heroin, the percentage of 胃 wave in the right side of TeA decreased significantly, but there was no significant difference in 尾 wave between the two groups. Conclusion: the frequency of rapid wave (尾, 尾 2) in the right TeA region of CPP rats induced by heroin is increased and the frequency of 胃 wave is decreased, which may be related to the drug seeking behavior of CPP rats induced by heroin.
【作者单位】：皖南医学院生理教研室;皖南医学院科研处;
【基金】：安徽省自然科学基金(090413096) 皖南医学院中青年科研基金(WK201201)~~
【分类号】：R749.6

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