早发型和晚发型难治性抑郁患者的临床特征比较

发布时间：2018-05-18 14:26

本文选题：早发型 + 晚发型　；参考：《上海交通大学学报(医学版)》2014年04期

【摘要】：目的比较早发型与晚发型难治性抑郁患者的临床特点。方法采用中位数切割法将370例成年难治性抑郁患者分为早发型组(n=193)和晚发型组(n=177),对两组患者的临床特征进行比较和分析。结果与晚发型组比较,早发型组男性、性格内向及完成9年制义务教育者的构成比更高(P0.001);当前发作病程更长,分别为(17.32±25.94)个月和(12.47±18.42)个月(P=0.015);与早发型组比较,晚发型组已婚者构成比和抑郁程度17项汉密尔顿抑郁量表(HAMD-17)总分和因子睡眠障碍得分均显著增高(P0.001),躯体共病构成比更高(P=0.008)。结论早发型与晚发型难治性抑郁患者的临床特征存在差异,可能与其潜在的病理生理学机制有关。
[Abstract]:Objective to compare the clinical characteristics of early onset and late onset refractory depression. Methods 370 adult patients with refractory depression were divided into early onset group and late onset group by median cutting method. The clinical characteristics of the two groups were compared and analyzed. Results compared with the late hairstyle group, the male with early hair style had a higher ratio of introversion and completion of nine-year compulsory education (P 0.001), and the duration of the attack was longer (17.32 卤25.94) months and 12.47 卤18.42 months (P 0.015), respectively, compared with the early onset group. In the late onset group, the total score and factor sleep disorder score of the 17 items of Hamilton Depression scale (Hamd-17) were significantly higher than those of the late onset group (P 0.001), and the ratio of somatic comorbidity was higher than that of the others (P 0.008). Conclusion there are differences in clinical features between early onset and late onset refractory depression, which may be related to its underlying pathophysiological mechanism.
【作者单位】：上海交通大学医学院附属精神卫生中心;
【基金】：“十五”国家科技攻关计划(2004BA720A21-02) 国家高技术研究发展计划(“863”计划)(2006AA02Z430) “十二五”国家科技支撑项目(2012BAI01B04) 国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873) 上海市科委医学(西医)引导类项目(134119b0400)~~
【分类号】：R749.4

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