弥散张量成像纵向分析轻度认知障碍高危个体的脑白质微结构改变

发布时间：2018-05-18 23:27

本文选题：阿尔茨海默病 + 认知障碍　；参考：《中国介入影像与治疗学》2017年11期

【摘要】：目的采用DTI纵向分析轻度认知障碍(MCI)高危个体的脑白质微结构改变。方法采用结构MRI、DTI及神经量表对102名受试者进行1年的随访观察,其中91名受试者认知保持正常(CN-stable组),11名受试者发展为MCI(CN-MCI组)。分析两组FA值和MD值的差异,并对其与MCI、认知能力的关系进行多因素Logistic回归分析。结果与CN-stable组比较,基线期CN-MCI组穹隆、左海马旁回白质的MD值增高(P0.05),随访期CN-MCI组穹隆、左海马旁回白质、左扣带回中部、胼胝体压部的MD值增高(P0.05),穹隆、左海马旁回白质的FA值减低(P0.05)。多因素Logistic回归分析显示,穹隆的MD值是CN-MCI向MCI发展的危险因素,左海马旁回白质的MD值是CDR评分增高的危险因素。结论在MCI临床确诊前,MCI高危个体的白质微结构发生变化,可作为AD早期相关脑改变的潜在影像学生物标志。
[Abstract]:Objective to analyze the microstructural changes of white matter in high risk individuals with mild cognitive impairment (MCI) by DTI. Methods 102 subjects were followed up for one year by structural MRI DTI and nerve scale. Among them, 91 subjects had normal cognition and 11 subjects in CN-stable group developed into MCI(CN-MCI group. The differences of FA and MD between the two groups were analyzed, and the relationship between FA and MCI and cognitive ability was analyzed by multivariate Logistic regression analysis. Results compared with the CN-stable group, the MD value of the white matter of the left parahippocampal gyrus in the baseline CN-MCI group was significantly higher than that in the CN-MCI group (P 0.05). In the follow-up period, in the CN-MCI group, the white matter of the left parahippocampal gyrus, the middle part of the left cingulate gyrus, and the middle part of the corpus callosum were increased (P 0.05). The FA value of the white matter in the left para-hippocampal gyrus was decreased (P 0.05). Multivariate Logistic regression analysis showed that the MD value of the fornix was the risk factor for the development of CN-MCI to MCI, and the MD value of the white matter in the left paracarpal gyrus was the risk factor for the increase of CDR score. Conclusion the changes of microstructures in white matter of individuals with high risk of MCI before clinical diagnosis can be used as a potential imaging biomarker for early related brain changes in AD.
【作者单位】：广州医科大学附属第二医院放射科;广州医科大学附属第二医院神经内科;
【基金】：广东省医学科研基金(A2014312)
【分类号】：R445.2;R749.1

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