精神分裂症患者青少年亲属前瞻、回溯记忆及遗传素质与侵害交互作用

发布时间：2018-05-18 23:10

本文选题：精神分裂症 + 一级亲属　；参考：《中国公共卫生》2015年08期

【摘要】：目的探讨精神分裂症患者青少年亲属前瞻、回溯记忆损伤情况及遗传素质与侵害对该人群前瞻、回溯记忆损伤的交互作用。方法选取山东省某精神卫生中心收治的92名精神分裂症患者的青少年子女或同胞作为亲属组和193名正常青少年作为对照组,采用前瞻回溯记忆问卷(PRMQ)和青少年侵害问卷自评版(JVQ)分别评估被试的前瞻、回溯记忆和侵害发生情况。结果多变量协方差分析结果显示,亲属组在PRMQ前瞻记忆和回溯记忆因子上的得分高于对照组[(19.3±6.5)分vs.(16.6±5.8)分,(19.3±6.2)分vs.(16.4±5.3分)](均P0.05);侵害程度在2个因子上的主效应有统计学意义(均P0.05);组别与侵害程度之间的交互作用均有统计学意义(均P0.05)。进一步的单变量方差分析结果显示,在亲属组中,经历多重侵害的青少年在前瞻记忆和回溯记忆因子上的得分高于未经历侵害的被试[(23.6±5.4)分vs.(16.9±6.6)分,(22.5±4.4)分vs.(16.8±6.1)分](均P0.01),在前瞻记忆因子上得分高于经历非多重侵害的被试[(23.6±5.4)分vs.(18.8±6.0)分](P0.05);而在对照组中,侵害程度在2个因子上的主效应均无统计学意义(均P0.05)。结论精神分裂症患者的青少年亲属在前瞻、回溯记忆上存在缺陷,侵害可能与该人群前瞻、回溯记忆改变有关,遗传素质与侵害对该人群前瞻、回溯记忆缺陷存在交互作用。
[Abstract]:Objective to investigate the prospect, retroactive memory impairment and the interaction between genetic quality and genetic impairment of relatives of schizophrenic patients. Methods 92 children or siblings of schizophrenia were selected as relatives group and 193 normal adolescents as control group in a mental health center in Shandong province. Prospective retrospective memory questionnaire (PRMQ) and adolescents' aggression questionnaire (JVQQ) were used to evaluate the prospective, retrospective memory and incidence of aggression. Results the multivariate covariance analysis showed that, The scores of PRMQ prospective memory and retroactive memory in relatives group were higher than those in control group [19.3 卤6.5 vs.(16.6 卤5.8 score, 19.3 卤6.2% vs.(16.4 卤5.3 score] (all P 0.05); the main effect of the degree of invasion on two factors was statistically significant (all P 0.05; the cross between group and invasion degree was significant). The interaction was statistically significant (P 0.05). Further univariate ANOVA results showed that in relatives, The scores of prospective memory and retroactive memory were significantly higher in adolescents who had experienced multiple aggression than those who had not (23.6 卤5.4) vs.(16.9 卤6.6) scores (22.5 卤4.4) vs.(16.8 卤6.1) (all P0.01s, higher scores in prospective memory factors than those in non-hyper-invasive subjects [23.6 卤5.4]). The scores of vs.(18.8 卤6.0) were 0. 05%, while in the control group, The main effects of the two factors on the degree of invasion were not statistically significant (P 0.05). Conclusion the relatives of the schizophrenic patients have defects in retroactive memory, which may be related to the prospect and the change of retroactive memory. Genetic diathesis and invasion have an interactive effect on the prospective and retroactive memory defects of the schizophrenic patients.
【作者单位】：山东大学护理学院;山东省精神卫生中心;
【基金】：山东省自然科学基金(ZR2013HM087) 山东大学创新基金重点项目(IFW12113)
【分类号】：R749.3

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