中国汉族人群补体因子H的基因多态性与精神分裂症的关联研究

发布时间：2018-05-22 08:37

  本文选题：精神分裂症 + 补体因子H基因　； 参考：《上海交通大学学报(医学版)》2017年07期

【摘要】：目的·探讨中国汉族人群补体因子H(CFH)基因单核苷酸多态性(SNP)位点与精神分裂症的相关性。方法·采用SNa Pshot法,对418例精神分裂症患者(病例组)和655个正常健康人(正常对照组)CFH基因5个SNP位点(rs800292、rs1061170、rs10801555、rs10922096、rs2019727)的基因型、等位基因、单体型频率进行比较。结果·成功检测5个SNP位点的基因型,关联分析显示rs1061170位点等位基因频率分布在病例组和对照组之间差异有统计学意义(校正P值=0.045),其他位点的基因型和等位基因频率分布在2组间差异均无统计学意义(均校正P值0.05)。由rs800292-rs1061170-rs10801555-rs10922096-rs2019727组成的单体型C-A-T-A-A频率分布在2组之间的差异有统计学意义(校正P值=0.013)。结论·CFH基因rs1061170位点等位基因多态性以及rs800292-rs1061170-rs10801555-rs10922096-rs2019727单体型C-A-T-A-A可能与中国汉族人群中的精神分裂症发病有关。
[Abstract]:Objective to investigate the association between SNPs of complement factor HG CFH gene and schizophrenia in Chinese Han population. Methods the genotypes, alleles and haplotype frequencies of 418 schizophrenic patients (case group) and 655 normal controls (5 SNP loci of the normal control group) were compared by SNa Pshot method. Results the genotypes of 5 SNP loci were detected successfully. Correlation analysis showed that the allelic frequency distribution of rs1061170 locus was significantly different between the two groups (P = 0.045, P = 0.045), but there was no significant difference in genotype and allele frequency distribution between the two groups. (P = 0.05). The frequency distribution of haplotype C-A-T-A-A composed of rs800292-rs1061170-rs10801555-rs10922096-rs2019727 was significantly different between the two groups (P = 0.013). Conclusion the allelic polymorphism of rs1061170 locus of CFH gene and rs800292-rs1061170-rs10801555-rs10922096-rs2019727 haplotype C-A-T-A-A may be associated with schizophrenia in Chinese Han population.
【作者单位】： 上海交通大学医学院附属精神卫生中心;
【基金】：国家自然科学基金(81671326) 国家重点研发计划“精准医学研究”重点专项(2016YFC0906402) 上海市科学技术委员会科研计划项目(17411970000) 中央高校基本科研业务费专项(16JXRZ06) 上海市精神卫生中心院级国际合作项目(2015-YJGJ-03)~~
【分类号】：R749.3
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本文编号：1921357