大鼠创伤性脑损伤后精神障碍的精神行为学改变

发布时间：2018-05-23 21:28

  本文选题：创伤性脑损伤 + 精神障碍　； 参考：《中国医科大学学报》2016年08期

【摘要】：目的利用改良FEENEY’S法建立大鼠创伤性脑损伤(TBI)模型,探讨TBI后精神障碍的精神行为学改变。方法将成年雄性SD大鼠随机分为正常对照组、TBI组和假手术组,每组各10只。采用改良FEENEY’S法建立大鼠TBI模型。TBI后15 d开始,分别依次进行旷场实验(OFT)和强迫游泳实验(FST)。记录OFT中大鼠5 min内的移动总距离(DMT)、平均速度(VM),记录FST中大鼠5 min内不动时间总和(ITT),观察大鼠的高警觉性、焦虑/抑郁和恐惧行为的变化。结果 TBI组大鼠的DMT[(1 228.10±204.97)cm]、运动VM[(4.09±0.68)cm/s]较假手术组[(1 660.01±332.09)cm、(5.53±1.10)cm/s]和正常对照组[(2 022.32±280.92)cm、(7.28±1.80)cm/s]均明显减少,差异均有统计学意义(P0.05)。TBI组大鼠的ITT[(149.88±27.36)s]较假手术组[(120.55±22.31)s]、正常对照组[(106.10±29.03)s]明显增加,差异有统计学意义(P0.05)。结论 TBI后,大鼠出现了焦虑/抑郁样精神行为异常。
[Abstract]:Objective to establish a model of traumatic brain injury (TBI) in rats with modified FEENEY'S method and to investigate the changes of mental disorders after TBI. Methods Adult male Sprague-Dawley rats were randomly divided into normal control group (TBI) and sham operation group (10 rats in each group). The rat model of TBI was established by modified FEENEY'S method. The open field experiment and forced swimming test were carried out 15 days later. The total distance and average velocity of OFT rats within 5 min were recorded, and the total immobility time of 5 min in FST rats were recorded. The changes of high alertness, anxiety / depression and fear behavior in rats were observed. 缁撴灉 TBI缁勫ぇ榧犵殑DMT[(1 228.10卤204.97)cm],杩愬姩VM[(4.09卤0.68)cm/s]杈冨亣鎵嬫湳缁刐(1 660.01卤332.09)cm,(5.53卤1.10)cm/s]鍜屾�ｅ父瀵圭収缁刐(2 022.32卤280.92)cm,(7.28卤1.80)cm/s]鍧囨槑鏄惧噺灏，

本文编号：1926440