甲基苯丙胺成瘾者情绪加工障碍的机制及其临床干预方法的整合研究进展

发布时间：2018-05-24 22:31

本文选题：甲基苯丙胺 + 情绪加工障碍　；参考：《生物化学与生物物理进展》2017年06期

【摘要】：近年来,在中国以甲基苯丙胺为代表的合成毒品使用人数已经超过海洛因等传统毒品,而且滥用问题日益严重.情绪问题是诱发甲基苯丙胺成瘾者复吸的重要因素.慢性使用甲基苯丙胺导致前额叶-边缘单胺类神经递质系统及相应神经环路结构和功能损害,是成瘾者出现情绪加工障碍的原因.本文从情绪体验、情绪识别与表达和线索诱发的情绪反应性三个方面总结甲基苯丙胺成瘾者情绪加工障碍的表现形式,及相应神经递质系统神经环路基础.指出易激惹和愤怒攻击行为是甲基苯丙胺成瘾过程需要重点关注的情绪问题,并进一步总结了甲基苯丙胺成瘾者情绪障碍的临床治疗和干预的潜在方法,包括药物手段、神经调控技术、认知与行为治疗等,特别是信息科学和脑科学的新技术,如虚拟现实整合多感觉通道的情绪信息,并结合神经调控技术可为甲基苯丙胺成瘾者情绪加工障碍的临床干预提供新的视角.
[Abstract]:In recent years, the number of synthetic drugs used in China, represented by methamphetamine, has exceeded that of traditional drugs such as heroin, and the problem of abuse has become increasingly serious. Emotional problems are an important factor in inducing relapse of methamphetamine addicts. Chronic use of methamphetamine leads to the damage of prefrontal and marginal monoamine neurotransmitter system and the corresponding neural loop structure and function, which is the cause of emotional processing disorders in addicts. This paper summarizes the manifestation of emotional processing disorders in methamphetamine addicts from three aspects: emotional experience, emotion recognition and expression, and emotional reactivity induced by cues, and the basis of the corresponding neurotransmitter system neural loop. Pointing out that irritability and anger aggression are emotional problems that need to be focused on in the process of methamphetamine addiction, and further summarizing the potential clinical treatment and intervention methods, including drug methods, for emotional disorders in methamphetamine addicts, Neuroregulatory techniques, cognitive and behavioral therapy, etc., especially new technologies in information science and brain science, such as virtual reality integrating multi-sensory emotional information, The combination of neuroregulatory techniques may provide a new perspective for the clinical intervention of emotional processing disorders in methamphetamine addicts.
【作者单位】：中国科学院心理健康重点试验室中国科学院心理研究所;中国科学院大学心理系;北京市教育矫治局;
【基金】：国家重点研发计划(2016YFC0800907) 国家重点基础研究发展计划(2015CB553500) 国家自然科学基金(31371035) 中国科学院心理健康重点实验室基金资助项目~~
【分类号】：R749.6

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