石杉碱甲治疗对老年血管性痴呆患者血液流变学及P300电位的影响

发布时间：2018-05-28 12:33

本文选题：石杉碱甲 + 血管性痴呆　；参考：《中国老年学杂志》2017年09期

【摘要】：目的探讨石杉碱甲治疗对老年血管性痴呆(VD)患者血液流变学及P300电位的影响。方法 90例老年VD患者随机分为观察组与对照组各45例,对照组给予基础治疗,观察组在对照组基础上加用石杉碱甲,对比两组血液流变学改变及P300电位情况。结果与治疗前比较观察组治疗后简易精神状态量表(MMSE)评分显著增高、临床痴呆量表(CDR)评分与日常生活活动能力(ADL)评分显著降低(P0.05);对照组上述指标治疗前后无显著差异(P0.05)。治疗后观察组MMSE、CDR、ADL评分显著优于对照组(P0.05)。观察组治疗前后血浆黏度、全血高切黏度、全血中切黏度、全血低切黏度差异有统计学意义(P0.05),血细胞比容无显著差异(P0.05),上述指标对照组治疗前后无统计学差异(P0.05),观察组治疗后显著低于对照组(P0.05);与治疗前比较,治疗后观察组P300电位波幅显著增加,潜伏期显著缩短(P0.05),对照组无明显变化(P0.05),观察组治疗后波幅显著比对照组高,而潜伏期则显著比对照组短(P0.05)。结论石杉碱甲能够有效改善VD患者微循环、增加脑血流量,从而提高老年VD患者的认知功能、自理能力和智能,改善痴呆症状,P300电位可作为评估VD病程与疗效监测的重要指标。
[Abstract]:Objective to investigate the effects of Huperzine A treatment on hemorheology and P300 potential in patients with vascular dementia (VD). Methods 90 elderly patients with VD were randomly divided into two groups: the observation group (n = 45) and the control group (n = 45). The control group was treated with basic therapy. The observation group was treated with Huperzine A on the basis of the control group. The changes of hemorheology and P300 potential were compared between the two groups. Results compared with those before treatment, the MMSE score of the observation group was significantly higher than that of the control group, and the scores of the clinical dementia scale and ADLL were significantly lower than those of the control group (P 0.05), but there was no significant difference before and after treatment in the control group. After treatment, the ADL score of MMSE CDRL in the observation group was significantly better than that in the control group (P 0.05). In the observation group, plasma viscosity, whole blood high shear viscosity and whole blood shear viscosity were observed before and after treatment. The difference of whole blood low shear viscosity was statistically significant (P 0.05), and there was no significant difference in blood cell volume (P 0.05). There was no significant difference between the above indexes before and after treatment in the control group (P 0.05), and the observation group was significantly lower than that in the control group (P 0.05) after treatment, and compared with the control group before and after treatment. After treatment, the amplitude of P300 potential in the observation group was significantly increased, and the latent period was shortened significantly (P 0.05), but no significant change was found in the control group (P 0.05). The amplitude of the wave in the observation group was significantly higher than that in the control group, but the latency was significantly shorter than that in the control group (P 0.05). Conclusion Huperzine A can effectively improve microcirculation and increase cerebral blood flow in VD patients, thus improving cognitive function, self-care ability and intelligence of senile VD patients. Improving P300 potential of dementia symptoms can be used as an important index to evaluate the course of VD and monitor curative effect.
【作者单位】：武汉市第六医院神经内科;
【分类号】：R749.13

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