阿尔茨海默病脑灰质核团微观结构的弥散峰度成像研究

发布时间：2018-05-28 13:41

本文选题：阿尔茨海默病 + 灰质核团　；参考：《临床放射学杂志》2017年07期

【摘要】：目的应用弥散峰度成像(DKI)研究阿尔茨海默病(AD)患者脑灰质核团微观结构变化的状况。方法搜集23例AD患者和24例健康对照者,行常规MRI序列及DKI扫描,手动测量尾状核头、壳核、苍白球、丘脑、红核、黑质、齿状核的DKI参数:弥散峰度(MK)、轴向峰度(Ka)、径向峰度(Kr)、平均弥散率(MD)、轴向弥散率(Da)、径向弥散率(Dr)及各向异性分数(FA)值。DKI参数诊断AD的能力采用ROC曲线分析,DKI各参数与MMSE评分之间的相关性采用Pearson相关分析。结果 AD组与健康对照组(HC组)相比,尾状核头的MK值、黑质的MK、Ka及Kr值升高(P0.05),丘脑的MK、Ka及Kr值、齿状核的Ka值减低(P0.05);丘脑、尾状核头、壳核、红核、齿状核的MD值升高(P0.05),丘脑、尾状核头、壳核、苍白球、齿状核的Da值升高(P0.05),尾状核头、苍白球及齿状核的Dr值升高(P0.05);苍白球、黑质的FA值减低(P0.05),尾状核头、红核、齿状核的FA值升高(P0.05)。苍白球Dr值的ROC曲线下面积(AUC=0.810)最大。各部位的MD、Da及Dr值、黑质的Ka值以及尾状核头的FA值与MMSE评分均呈负相关(P0.05);丘脑的MK、Ka值以及红核、黑质的FA值与MMSE评分呈正相关(P0.05)。结论 AD患者灰质核团的微结构存在病理性变化,利用DKI可以定量评估灰质核团微结构变化的状况,灰质核团中苍白球的Dr值是鉴别AD与HC的最佳指标。
[Abstract]:Objective to study the microstructure of gray matter nuclei in patients with Alzheimer's disease (AD) by diffusion kurtosis imaging (DKI). Methods 23 patients with AD and 24 healthy controls were examined by routine MRI sequence and DKI scanning. The head of caudate nucleus, putamen nucleus, globus pallidus, thalamus, red nucleus and substantia nigra were measured manually. DKI parameters of dentate nucleus: diffusion kurtosis, axial kurtosis, radial kurtosis, average diffusion rate, axial diffusion rate, radial dispersion rate, and anisotropic fractional FAA value. The ability of DKI parameters to diagnose AD by ROC curve analysis The correlation with MMSE score was analyzed by Pearson correlation analysis. Results compared with the healthy control group (HC), the MK values of the head of caudate nucleus, the values of MKN Ka and Kr in substantia nigra increased P 0.05, the values of MKK and Kr in thalamus and dentate nucleus decreased (P 0.05), the thalamus, head of caudate nucleus, putamen nucleus and red nucleus decreased. The MD value of dentate nucleus increased P0.05A, thalamus, head of caudate nucleus, putamen nucleus, globus pallidus, nucleus dentate nucleus, head of caudate nucleus, globus pallidus and dentate nucleus increased P0.05; FA value of globus pallidus, substantia nigra decreased P0.05, head of caudate nucleus, red nucleus. The FA value of dentate nucleus was higher than that of P0.05. The area under the ROC curve of Dr value of globus pallidus was the largest. There was a negative correlation between the MMSE score and the values of MDK Da and Dr, Ka value of substantia nigra and FA value of head of caudate nucleus, but there was a positive correlation between MKK Ka value of thalamus, FA value of substantia nigra and MMSE score. Conclusion there are pathological changes in the microstructures of the gray matter nuclei in AD patients. DKI can be used to quantitatively evaluate the changes of the microstructures of the gray matter nuclei. The Dr value of the globus pallidus in the gray matter nuclei is the best index for differentiating AD from HC.
【作者单位】：湖北省十堰市太和医院放射科;大连医科大学附属第一医院放射科;
【分类号】：R445.2;R749.16

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