多域遗忘型轻度认知障碍与血管性非痴呆认知障碍的~1H-MRS分析

发布时间：2018-05-28 17:58

本文选题：多域遗忘型轻度认知障碍 + 血管性非痴呆认知障碍　；参考：《临床放射学杂志》2015年09期

【摘要】：目的探讨1H-MRS在多域遗忘型轻度认知障碍(M-a MCI)与血管性非痴呆认知障碍(VCIND)鉴别诊断中的应用价值。方法对30例M-a MCI、24例VCIND患者及20名认知功能正常老年人(NC组)行多体素1H-MRS检查,以左侧海马、扣带后回、额叶白质及侧脑室体旁白质为兴趣区,检测N-乙酰天门冬氨酸(NAA)、谷氨酸(Glu)、肌醇(m I)及肌酸(Cr)的峰下面积,比较三组间不同脑区NAA/Cr、Glu/Cr及m I/Cr比值的差异。结果 Ma MCI组及VCIND组左侧海马、扣带后回、额叶白质及侧脑室体旁白质区的NAA/Cr比值均较NC组降低,差异有显著性(P0.05);但M-a MCI组和VCIND组在各脑区的NAA/Cr比值差异均无显著性(P0.05)。M-a MCI组扣带后回Glu/Cr比值较VCIND组与NC组明显降低,差异有显著性(P0.05);三组间的Glu/Cr比值在其他脑区差异均无显著性(P0.05)。M-a MCI组在海马及扣带回的m I/Cr比值较VCIND组和NC组明显升高,差异有显著性(P0.05);VCIND组在额叶白质区的m I/Cr比值较M-a MCI组升高,差异有显著性(P0.05)。结论 M-a MCI及VCIND患者脑内m I及Glu代谢存在区域性的差异,1H-MRS是鉴别M-a MCI及VCIND的有效方法之一。
[Abstract]:Objective to evaluate the value of 1H-MRS in the differential diagnosis of multiple amnesia mild cognitive impairment (M-a MCI) and vascular non-dementia cognitive impairment (VCIND). Methods 30 patients with M-a MCI (n = 24) with VCIND and 20 patients with normal cognitive function (n = 20) were examined by multibody 1H-MRS. The left hippocampus, posterior cingulate gyrus, white matter of frontal lobe and paraventricular white matter of lateral ventricle were used as the area of interest. The subpeak areas of NAA, glutamate, inositol I) and creatine (Cr) were measured, and the differences of NAA / Cr / Cr and m I/Cr ratios in different brain regions among the three groups were compared. Results the ratio of NAA/Cr in left hippocampus, posterior cingulate gyrus, white matter of frontal lobe and white matter of lateral ventricle in Ma MCI group and VCIND group was lower than that in NC group. There was no significant difference in the ratio of NAA/Cr between M-a MCI group and VCIND group in all brain regions. The ratio of Glu/Cr in the posterior cingulate gyrus of M-a MCI group and M-a MCI group was significantly lower than that of VCIND group and NC group. There was no significant difference in the ratio of Glu/Cr between the three groups in other brain regions. The ratio of m I/Cr in hippocampus and cingulate gyrus in group M a MCI was significantly higher than that in group VCIND and group NC. The ratio of m I/Cr in the white matter area of frontal lobe in VCIND group was significantly higher than that in M-a MCI group (P 0.05). Conclusion there is a regional difference in the metabolism of MI and Glu between M-a MCI and VCIND patients. 1H-MRS is one of the effective methods for differentiating M-a MCI and VCIND.
【作者单位】：南京医科大学附属苏州医院放射科;南京医科大学附属苏州医院神经科;
【分类号】：R749.1

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